FORMULATION AND COMPARATIVE EVALUATION OF ONDANSETR ON HYDROCHLORIDE MOUTH DISSOLVING TABLETS IN INDIA (Record no. 11134)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210105126.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12044 |
| Author | Abdul Raheem T. |
| 245 ## - TITLE STATEMENT | |
| Title | FORMULATION AND COMPARATIVE EVALUATION OF ONDANSETR ON HYDROCHLORIDE MOUTH DISSOLVING TABLETS IN INDIA |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(9) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 57-64p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The aim of the present study was to prepare the ond<br/>ansetron hydrochloride Mouth Dissolving Tablets (MD<br/>Ts) followed by its <br/>comparison with ethical and non-ethical (generic) m<br/>arketed tablets. <br/>Methods: <br/>Prior to the formulation, drug excipient compatibil<br/>ity study was carried out by FTIR spectroscopy. The<br/> λ<br/>max <br/>was determined by UV <br/>spectroscopy. The ondansetron hydrochloride MDTs we<br/>re prepared by direct compression method using Sodi<br/>um Starch Glycolate (SSG) as super <br/>disintegrant and camphor as a sublimating agent. Th<br/>en the prepared MDTs were subjected to evaluation o<br/>f post compression parameters such as <br/>thickness and diameter, weight variation, wetting t<br/>ime, hardness, friability, disintegration and disso<br/>lution. The results obtained were compared <br/>with that of ethical and non-ethical marketed ondan<br/>setron hydrochloride 4 mg tablets. <br/>Results: <br/>The λ<br/>max <br/>was found at 310 nm. FTIR<br/>study revealed that excipients used in the prepared<br/> formulations are compatible with the drug. The <br/>thickness and diameter was in the range of 2.646 to<br/> 3.27 mm and 6.0 to 8.12 mm, respectively. Friabili<br/>ty was in the range of 0.43 to 0.88 % and had <br/>a slightly higher friability (1.27%) for sublimated<br/> tablets. Wetting time and disintegration time were<br/> in the range of 15 to 40 sec and 23 to 50 sec, <br/>respectively. The 100 % drug release was found with<br/>in 180 sec for all the codes. These results were th<br/>en compared with non-ethical film coated <br/>ondansetron marketed tablets. <br/>Conclusion: <br/>Ondansetron hydrochloride MDT 4 mg tablets prepared<br/> in the laboratory were under specified IP limits. <br/>The experimental findings <br/>demonstrated that any of these ethical and non-ethi<br/>cal tablets of ondansetron hydrochloride can be sel<br/>ected, advised by the physician or <br/>pharmacist, as per the patient’s need and economica<br/>l status. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12045 |
| Co-Author | Singh, Ranjeet |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/33840/20641 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 10/02/2020 | 2020874 | 10/02/2020 | 10/02/2020 | Articles Abstract Database |