SIMULTANEOUS ESTIMATION OF MOMETASONE FUROATE AND FORMOTEROL FUMAR ATE BY HPLC METHOD IN ROTACAPS (Record no. 11142)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210145417.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12055 |
| Author | Zanwar, Aarti S. |
| 245 ## - TITLE STATEMENT | |
| Title | SIMULTANEOUS ESTIMATION OF MOMETASONE FUROATE AND FORMOTEROL FUMAR ATE BY HPLC METHOD IN ROTACAPS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 12-16p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>To develop and validate a <br/>simple and sensitive RP<br/>-HPLC method for th<br/>e simultaneous determination of<br/> mometasone furoate<br/> (MOM)<br/> and <br/>formoterol fumarate (FOR) <br/>in pharmaceutical dosage forms.<br/>Method<br/>s: <br/>In <br/>RP<br/>-HPLC method<br/>, chromatographic separation was achieved using<br/> a mixture of a solvent system consisting of methanol<br/>–water (pH <br/>3.5) in the ratio of 85:15 % v/v<br/> at a flow rate of<br/> 1 ml<br/>/min <br/>and <br/>detection was carried out at 225 nm. <br/>Result<br/>s: <br/>The run time for the simultaneous estimation of drugs for the proposed method was 1<br/>0 min<br/> as drugs eluted at 5.217 min (MOM) and 8.65<br/>0 <br/>min<br/> (FOR).<br/> The linearity <br/>was found in the range of 33.33<br/>-299.<br/>97 μg<br/>/ml<br/> and 1<br/>-<br/>9 μg<br/>/ml<br/> for MOM<br/> and FOR<br/>, respectively.<br/> The<br/> values<br/> of limit of <br/>detection and limit of quantification<br/> were 3.634, 0.266 μg<br/>/ml<br/> and 11.014, 0.807 μg<br/>/ml<br/>, which <br/>indicates the sensitivity of the method for the <br/>estimation of MOM and FOR, respectivel<br/>y. The <br/>results of recovery studies for both the drugs were <br/>within the range i.e.<br/> 98.8<br/>7-101.48 <br/>% <br/>which <br/>indicates the accuracy of the method<br/>. Relative standard deviation<br/> obtained f<br/>rom<br/> repeatability<br/> and <br/>reproducibility studies <br/>were <br/>less than 2<br/>%<br/>indicate<br/>s the <br/>precision of the method.<br/> The <br/>proposed method w<br/>as<br/> validated according to ICH guidelines.<br/>Conclusio<br/>n: <br/>The proposed<br/> RP<br/>-HPLC method was found to <br/>be sensitive <br/>and precise<br/> because of the low LOD<br/>, LOQ and % RSD values (<2). The <br/>proposed <br/>work <br/>does not require ace<br/>tonitrile and ion pairing reagent<br/> as compared<br/> to the reported method<br/>s. Therefore<br/>, method can be used <br/>preferabl<br/>y for routine analysis due to its simplicity and economic <br/>advantages. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12056 |
| Co-Author | Sen, Dhanya B. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/24799/19143 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 10/02/2020 | 2020881 | 10/02/2020 | 10/02/2020 | Articles Abstract Database |