ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SI MULTANEOUS ESTIMATION OF CURCUMIN AND CYCLOSPORINE BY RP-HPLC (Record no. 11145)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210151311.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12061 |
| Author | Desai, Neha |
| 245 ## - TITLE STATEMENT | |
| Title | ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SI MULTANEOUS ESTIMATION OF CURCUMIN AND CYCLOSPORINE BY RP-HPLC |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 26-33p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The present work was undertaken with an aim to deve<br/>lop and validate a rapid reverse-phase high-perform<br/>ance liquid chromatography <br/>(RP-HPLC) method for the estimation of curcumin and<br/> cyclosporine in the capsule dosage form. <br/>Methods: <br/>The RP-HPLC method for the simultaneous estimation o<br/>f curcumin and cyclosporine was developed using Agi<br/>lent (Infinity 1260) HPLC <br/>system and Eclipse XDB-C18 (4.6 x 150 mm i.d., 5μ) <br/>stationary phase. The optimized mobile phase compri<br/>sed of acetonitrile: water: methanol (50: <br/>10: 40 v/v/v) pumped at a flow rate of 0.5 ml/min. <br/>Separation of drugs was achieved in an isocratic mo<br/>de and elution was monitored using PDA <br/>detector at 214 nm. The method was validated as per<br/> ICH-Q2R1 guidelines. <br/>Results: <br/>Retention time of the curcumin and cyclosporine wer<br/>e found to be 3.073 min and 6.373 min with the corr<br/>elation coefficient (R<br/>2<br/>) of 0.9993 <br/>and 0.998 respectively. The response of curcumin an<br/>d cyclosporine was found linear in the concentratio<br/>n range of 8-48 μg/ml and 4-24 μg/ml <br/>respectively. The percent recovery values were foun<br/>d in the range of 97-103% indicating satisfactory a<br/>ccuracy of the method. The percent relative <br/>standard deviation (% RSD) values for the precision<br/> study was less than 2 which suggest that the metho<br/>d is precise. <br/>Conclusion: <br/>The proposed method was found accurate, precise and<br/> specific for the determination of curcumin and cyc<br/>losporine in bulk as well as in <br/>capsule dosage form. Thus, the present method can b<br/>e used for routine analysis and quality control of <br/>curcumin and cyclosporine in bulk and <br/>capsule dosage form. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12062 |
| Co-Author | Momin, Munira |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/28975/19148 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 10/02/2020 | 2020884 | 10/02/2020 | 10/02/2020 | Articles Abstract Database |