INNOVATIVE METHOD DEVELOPMENT AND FORCED DEGRADATION STUDIES FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND LEDIPASVIR BY RP HPLC (Record no. 11146)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210151942.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12064 |
| Author | Reddy, B. Anjaneyulu |
| 245 ## - TITLE STATEMENT | |
| Title | INNOVATIVE METHOD DEVELOPMENT AND FORCED DEGRADATION STUDIES FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND LEDIPASVIR BY RP HPLC |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 34-41p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>To develop an innovative, rapid, simple, cost<br/>-effective<br/>, stability indicating reverse phase<br/>-high performance liquid chromatography (RP<br/>-<br/>HPLC) method for simultaneous estimation of ledipasvir (LP) and sofosbuvir (SB) in combination pill dosage form.<br/>Method<br/>s: <br/>The method was developed using C8 column, 250<br/> mm<br/> x 4.6 mm, 5<br/> mm <br/>using mobile section comprising of 0.1%<br/> (v/v)<br/> orthophosphoric <br/>acid buffer<br/> at <br/>pH 2.2<br/> and acetonitrile in the ratio of 45:55 that was pumped through the column at a flow rate of 0.8 ml/min. Temperature <br/>was <br/>maintained at 30<br/> °C, the effluents w<br/>ere monitored at 260 nm with the help of usage of PDA detector.<br/>Result<br/>s: <br/>The retention time of LP and SB were found to be 2.246 min and 3.502 min.<br/> The approach was found to be linear with the variety of 9<br/>-36<br/>μg<br/>/ml<br/> and 40<br/>-<br/>240 μg<br/>/ml<br/> for LP and SB respectively, the assay of estimated compounds were found to be 99.65% and 99.73% w/v for LP and SB <br/>respectively.<br/>Conclusio<br/>n: <br/>The pressured samples changed into analyzed and this proposed a technique turned into determined to be particular and stability <br/>indicating as no interfering peaks of decay compound and excipients were observed. Hence, the approach was easy and economica<br/>l that may be <br/>efficiently applied for simultaneous estimation of both LP and SB in bulk and combination tablet system |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12065 |
| Co-Author | Md. Irshad Alam |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/29347/19150 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 10/02/2020 | 2020885 | 10/02/2020 | 10/02/2020 | Articles Abstract Database |