ANTISICKLING ACTIVITY EVALUATION OF FRACTIONS OBTAINED FROM WHOLE EXTRACTS OF NEWBOULDIA LAEVIS P. BEAUV (BIGNONIACEAE ) (Record no. 11148)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200210152903.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12067 |
| Author | Dermane, Affo |
| 245 ## - TITLE STATEMENT | |
| Title | ANTISICKLING ACTIVITY EVALUATION OF FRACTIONS OBTAINED FROM WHOLE EXTRACTS OF NEWBOULDIA LAEVIS P. BEAUV (BIGNONIACEAE ) |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 42-46p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>This study aims to <br/>evaluate the fractions from whole extracts of roots and stem barks of <br/>Newbouldia <br/>laevis<br/>and their effect on sickling<br/>. <br/>Method<br/>s: <br/>Hydroethanolic <br/>extracts <br/>of stem bar<br/>ks and root<br/>s of <br/>Newbouldia<br/> laevis<br/>we<br/>re fractionated by <br/>the technics of cold precipitation in ethanol. <br/>The fractions obtained after phytochemical<br/> screening were subjected to<br/> Emmel test to evaluate their anti<br/>-sickling activity. Active fractions were <br/>tested for DPPH and AAPH assay<br/> (AAPH induced m<br/>embrane<br/> lipoperox<br/>idation<br/> and evaluation of <br/>reduction of <br/>hemolysis)<br/>. <br/>Result<br/>s: <br/>Two fractions were obtained from each whole extrac<br/>t: supernatant and pellet fractions.<br/> Supernatants fractions obtained from whole roots <br/>bark<br/>s extract and stem barks extract <br/>at a concentration of 3<br/>0 mg<br/>/ml<br/> reduced sickling up respectively to 7<br/>% and <br/>10%<br/> against 86% for the control<br/>. <br/>Pellets fractions obtained from <br/>the both<br/> extracts induced coagulation of SS blood<br/> at 30 mg<br/>/ml<br/> against 86% for the control<br/>. <br/>Conclusio<br/>n: <br/>Supernatants fractions of hydroethano<br/>lic whole extract of roots and stem backs of <br/>Newbouldia <br/>laevis<br/> promise as the potential source of <br/>active molecules against sickle cell disease. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12068 |
| Co-Author | Kepegba, Kafui |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30112/19151 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 10/02/2020 | 2020886 | 10/02/2020 | 10/02/2020 | Articles Abstract Database |