MUTANT P21 PEPTIDES COULD ACT AS AN IMPROVED CYCLIN A INHIBITORS FOR CANCER THERAP Y (Record no. 11155)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200211095310.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200211b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12076 |
| Author | Agarwal, Tarun |
| 245 ## - TITLE STATEMENT | |
| Title | MUTANT P21 PEPTIDES COULD ACT AS AN IMPROVED CYCLIN A INHIBITORS FOR CANCER THERAP Y |
| Remainder of title | : AN IN SILICO VALIDATION |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(2) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 59-64p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The present study delineates <br/>the <br/>generation of mutant peptide library from a known anticancer peptide, p21 <br/>and <br/>in silico<br/> evaluation <br/>for<br/>their <br/>affinity towards cyclin<br/>. A substrate binding groove. <br/>Method<br/>s: <br/>Mutant <br/>peptide library <br/>was created based on their AntiCP<br/> score<br/> and was docked with cyclin A using ClusPro2.0 web server. The docked <br/>structures were further simulated into an aqueous environment using Gromacs 4.5.6. Visualization was<br/> performed using PyMol software and <br/>interaction analysis was done using Discovery Studio Visualizer 4.1 Client and LigPlot plus tool.<br/>Result<br/>s: <br/>A total of 57 mutant peptides were generate<br/>d; <br/>out of which only 3 namely, K3C <br/>(Lys3Cys)<br/>, K3F<br/> (Lys3Phe)<br/>, and K3W (<br/>Lys3Trp) <br/>had<br/> a <br/>greater<br/> affinity for cyclin A than <br/>WILD<br/> p21 peptide<br/> (HSKRRLIFS<br/>). Molecular dynamic s<br/>imulation studies showed that <br/>the <br/>peptides remained docked <br/>into the substrate binding groove throughout the run. Among all the peptides, K3C <br/>showed <br/>a <br/>significantly higher<br/> negative binding energy <br/>with <br/>cyclin A <br/>as<br/> compar<br/>ed<br/> to WILD. <br/>Conclusio<br/>n: <br/>The<br/> overall<br/> results<br/> suggested that <br/>K3C<br/> mutant peptide had ~30 % higher affinity towards cyclin A and thus, could further be explored <br/>for its anticancer potential. The study also <br/>provides<br/> an insight into the crucial interactions governing the recognition of substrate binding groove of <br/>cyclin A for<br/> the<br/> development <br/>of novel peptide<br/>-based<br/> anticancer therapeutics |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12077 |
| Co-Author | Annamalai, Nithyanan |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30577/19155 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 11/02/2020 | 2020889 | 11/02/2020 | 11/02/2020 | Articles Abstract Database |