ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM (Record no. 11183)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212103234.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12128 |
| Author | Sharma, Saruchi |
| 245 ## - TITLE STATEMENT | |
| Title | ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(4) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 98-103p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>This study involves the synthesis of <br/>Gum tragacanth <br/>(gt) based interpenetrating polymer network (ipn) a<br/>nd its utilization for sustained <br/>release of anti-ulcerative drug i.e. pantoprazole s<br/>odium. <br/>Methods: <br/>IPN was synthesized from Gum tragacanth, polyacryli<br/>c acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in <br/>distilled water. Further, acryamide <br/>(aam) and methylmethacrylate (mma) was added and th<br/>en kept for overnight. Later on, lipase and glutara<br/>ldehyde were added. Homopolymers and <br/>the unreacted monomers were removed using acetone. <br/>Synthesized IPN was dried at 50 °C for further stud<br/>y. <br/>Synthesized ipn was swelled in water and the drug w<br/>as added to it. The drug was entrapped in the pores<br/> of the synthesized ipn and then drug <br/>release behavior was studied using uv-vis spectroph<br/>otometer. <br/>Results: <br/>Gt, <br/>paa and mma based crosslinked IPN were synthesized <br/>using lipase-glutaraldehyde as initiator-crosslinke<br/>r system. The synthesized IPN <br/>was pH sensitive and possessed the desired swelling <br/>capacity required for the controlled and systematic<br/> liberation of pantoprazole sodium at 37 °C. <br/>The kinetic of drug release was studied and found t<br/>hat lateral diffusion (D<br/>L<br/>) of drug was higher as compared to the initial dif<br/>fusion (D<br/>I<br/>). The <br/>prepared IPN can be used as prospective carrier for<br/> prolonged drug delivery. <br/>Conclusion: <br/>A novel pH sensitive and colon targeted IPN was synt<br/>hesized. It acts as an effective device for the con<br/>trolled release of drug <br/>pantoprazole sodium. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12129 |
| Co-Author | Vaneet Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/31043/19676 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 12/02/2020 | 2020916 | 12/02/2020 | 12/02/2020 | Articles Abstract Database |