ANTI -CANCER POTENTIAL OF POLYSACCHARIDE ISOLATED FROM METHANOLIC EXTRACT OF TINOSPORA CORDIFOLIASTEM BARK (Record no. 11193)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212114127.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12146 |
| Author | Ludas, Antony |
| 245 ## - TITLE STATEMENT | |
| Title | ANTI -CANCER POTENTIAL OF POLYSACCHARIDE ISOLATED FROM METHANOLIC EXTRACT OF TINOSPORA CORDIFOLIASTEM BARK |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(5) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 43-47p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The exploration of the anticancer potential of polysaccharide isolated from the methanolic extract of <br/>Tinospora<br/> cordifolia<br/> (<br/>T. cordifolia<br/>) <br/>stem bark against breast cancer in DMBA<br/>-induced female albino Wistar rat models were examined by various hematological parameters. <br/>Method<br/>s: <br/>Analysis of Red blood cell (<br/>RBC<br/>), White blood cell (<br/>WBC<br/>) and platelet<br/> level, Tumor markers Carcino<br/> Embryonic Antigen<br/> (CEA) and Cancer <br/>Antigen 15.3 (<br/>CA 15.3) in the serum, was done in the normal, cancer and compound treated rats usin<br/>g specific kits. Histological studies were <br/>performed to examine the changes in the tissue morphology and cell patterns in breast tissue. <br/>Result<br/>s: <br/>The decreased levels of RBC, WBC and platelets in<br/> 7,12<br/>-Dimethylbenz<br/> [a]<br/> anthracene (<br/>DMBA<br/>)-induced <br/>breast <br/>cancer<br/> (Group III) animals were <br/>revived to the normal conditions in polysaccharide treated breast cancer (Group IV) animals as that of normal (Group I). The level of tumor markers<br/> CEA <br/>and<br/> CA 15.3, was found elevated in serum of DMBA-<br/>induced breast cancer g<br/>roups (Group III) when compared to their levels in the normal groups <br/>(Group I) whereas polysaccharide treatment (Group IV) prevented this rise in the levels of tumor markers. The histological studies on the breast tissue <br/>samples of all the groups showed th<br/>e appropriate features where the normal (Group I) animals were characterized with<br/> normal cells uniformly <br/>arranged without any change in orientation and morphology, DMBA-<br/>induced cancer (Group III) animals showed<br/> an improper orientation of cells <br/>arranged as <br/>glandular structures, as nest, or cords of various sizes or as solid sheets foci of necrosis in some areas with<br/> margins infiltrating, pushing, <br/>circumcised or mixed and the polysaccharide treated (Group IV) animals showed results resembling that of the norm<br/>al (Group I) animals |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12147 |
| Co-Author | Sabapathy Indu |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/19756/19863 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 12/02/2020 | 2020926 | 12/02/2020 | 12/02/2020 | Articles Abstract Database |