CHARACTERIZATION , IN VITRO ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF FUNGAL ENDOPHYTIC EXTRACTS OF ANDROGRAPHIS PANICULATA LEAVES IN CCL Original Article 4 INDUCED HEPATOTOXICITY (Record no. 11202)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213102043.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12163 |
| Author | Puri, Smita K. |
| 245 ## - TITLE STATEMENT | |
| Title | CHARACTERIZATION , IN VITRO ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF FUNGAL ENDOPHYTIC EXTRACTS OF ANDROGRAPHIS PANICULATA LEAVES IN CCL Original Article 4 INDUCED HEPATOTOXICITY |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(1) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 44-54p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>To isolate and characterize the endophytic fungi from the leaves of<br/>Andrographis paniculata <br/>for free radical scavenging antioxidant <br/>and <br/>hepatopr<br/>otective activity against <br/>CCl<br/>4<br/>Method<br/>s: <br/>Two fungal <br/>endophytes, <br/>APLF<br/>-3 (<br/>Andrographis <br/>paniculata<br/> leaf fungi<br/>-3) and APLF<br/>-4 (<br/>Andrographis <br/>paniculata<br/> leaf fungi<br/>-4) <br/>were isolated <br/>from<br/> leaves of <br/>Andrographis <br/>paniculata<br/>to get chloroform (A3C, A4C), ethyl acetate (A3EA, A4EA) and n butanol (A3nB, A4nB) extracts. rDNA <br/>sequencing by PCR technique was carried out for identification of APLF<br/>-3 and APLF<br/>-4. All the APLF<br/>-3 and APLF<br/>-4 extracts were assayed for <br/>in vitro<br/>free radical scavenging activity against 2, 2<br/>-diphenyl<br/>-1-picrylhydrazyl (DPPH), hydroxyl radical and redu<br/>cing power. Then, A4EA and A4nB were <br/>screened for hepatoprotective activity against CCl<br/> induced hepatotoxicity<br/>4<br/>Result<br/>s: <br/>The endophytic fungi, APLF<br/>-3 and <br/>APLF<br/>-4, were identified as <br/>Phyllosticta sp. ZLY<br/>-2010 isolate M13 <br/>and <br/>Aspergillus <br/>tubingensis<br/> strain Cs/7/2 <br/>respectively based on their morphological and molecular characterization. A4EA and A4nB showed significant <br/>in vitro<br/> free radical scavenging <br/>activity as compared to other extracts. <br/>A4EA and A4nB (50 mg/kg <br/>and<br/>100 mg/kg) reversed the increased serum biochemical parameters as <br/>compared to CCl<br/> induced hepatotoxicity at 50 mg/kg and<br/>100 mg/kg doses.<br/>4<br/>Conclusio<br/>n: <br/>These findings suggested that the extracts (A4EA and A4nB) obtained from <br/>endophytic fungi APLF<br/>-4 contributed towards <br/>hepatoprotective activity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12164 |
| Co-Author | Habbu, Prasanna V. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/26832/16538 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 13/02/2020 | 2020935 | 13/02/2020 | 13/02/2020 | Articles Abstract Database |