ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS DETERMINATION OF UBIDECARENONE AND VITAMIN E ACETATE IN CAPSULE DOSAGE FORM BY HPLC (Record no. 11210)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213114544.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12179 |
| Author | Grace, A. Caroline |
| 245 ## - TITLE STATEMENT | |
| Title | ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS DETERMINATION OF UBIDECARENONE AND VITAMIN E ACETATE IN CAPSULE DOSAGE FORM BY HPLC |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(1) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 79-84p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective:<br/>To develop and val<br/>idate a new simple, accurate,<br/> precise <br/>and sensitive<br/> high performance liquid chromatographic method (<br/>HPLC<br/>) method for <br/>simultaneous estimation of ubidecarenone and vitamin E acetate in capsule<br/> dosage form as per <br/>international conference on harmonization<br/> (ICH<br/>) guidelines.<br/>Method<br/>s: <br/>The chromatographic separation of drugs were achieved using hypersil<br/> C<br/>8<br/>Result<br/>s: <br/>The optimized method produced sharp peaks with good resolution, minimum tailing factor and satisfactory retention time were f<br/>ound to <br/>be <br/>5.745<br/> min<br/> and 12.565<br/> min<br/> for vitamin E acetate and ubidecarenone respectively.<br/> The method was linear in the range of 60<br/>-180 μg<br/>/ml<br/> for <br/>ubidecarenone and 20<br/>-60<br/> μg<br/>/ml<br/> for vitamin E acetate<br/> with<br/> a correlation coefficient <br/>of 0.99<br/>9 and 0.99<br/>93 respectively. <br/>Mean recoveries observed for <br/>ubidecarenone and vitamin E acetate were 99.85% and 99.73% respectively. <br/>The<br/> percentage relative standard deviation<br/> (% RSD<br/>) of peak area for <br/>system precision, method preci<br/>sion<br/>, and<br/> intermediate precision were <br/>found to be less than 0.37<br/>%. <br/>The<br/> lower degree of % <br/>RSD <br/>obtained has<br/> proved <br/>that the method was precise and robust.<br/> column <br/>(25<br/>0 mm<br/> x 4.<br/>6 mm<br/>, 5μ<br/>) in isocratic elution mode with <br/>a mobile phase of <br/>methano<br/>l: ethano<br/>l: n-hexane <br/>(80:10:10<br/> v/v/v<br/>) at a flow rate of 1 ml<br/>/min with ultra<br/>-violet<br/> (UV<br/>) detection at 210 nm.<br/>Conclusio<br/>n: <br/>A new simple HPLC method was developed and validated as per ICH guidelines for the simultaneous estimation of ubidecarenone and<br/>vitamin E<br/> acetate and the method can be <br/>effectively<br/> applied for the routine analysis of active pharmaceutical ingredient <br/>(API<br/>) and formulations. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12180 |
| Co-Author | Prabha, T. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30054/16549 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 13/02/2020 | 2020940 | 13/02/2020 | 13/02/2020 | Articles Abstract Database |