NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROC HLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN (Record no. 11223)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213144014.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12206 |
| Author | Dholakia, Mansi |
| 245 ## - TITLE STATEMENT | |
| Title | NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROC HLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.10(12) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 5-13p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The present research work aims at describing the fo<br/>rmulation and evaluation of the ocular delivery sys<br/>tem of moxifloxacin <br/>hydrochloride (MH) based on the concept of ion sens<br/>itive in situ gelations. <br/>Methods: <br/>In situ gel was prepared by a hot method using 0.6%<br/> of gelrite, 0.25% hydroxypropylmethylcellulose (HP<br/>MC K<br/>4<br/>M) and 0.023% tamarind <br/>gum as bioadhesive polymers for sustained drug rele<br/>ase. Optimization was done by Box Behnken Design wi<br/>th different concentration of gelrite (X<br/>1<br/>), <br/>HPMC K<br/>4<br/>M (X<br/>2<br/>) and tamarind gum (X<br/>3<br/>) as independent variables. In situ gel was optimiz<br/>ed based on mucoadhesion index (Y1), Gel strength (<br/>Y2) <br/>and <br/>in vitro<br/> drug release (Y3). Influence of the quantitative v<br/>ariable on the dependent variable was predicted by <br/>a polynomial equation. <br/>Results: <br/>Infrared spectroscopy excluded any interaction betw<br/>een drug and excipients. The selected independent v<br/>ariables significantly influenced <br/>the responses and were able to sustain the drug rel<br/>ease. The prepared gel with a pH of 6.8 to 7.4 exhi<br/>bited non-newtonian flow with no ocular <br/>irritation. The formulation remained stable with no<br/> change in pH and viscosity after 30 d of stability <br/>study. <br/>Conclusion: <br/>Thus, moxifloxacin hydrochloride (MH) in situ gel i<br/>s a viable alternative to a conventional delivery s<br/>ystem with the properties of <br/>sustained drug release, prolonged ocular retention,<br/> and improved corneal penetration. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12207 |
| Co-Author | Dave, Richa |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| International Standard Serial Number | 2656-0097 |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/26979/16278 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 13/02/2020 | 2020949 | 13/02/2020 | 13/02/2020 | Articles Abstract Database |