FORMULATION AND EVALUATION OF DASATINIB LOADED SOLID LIPID NANOPARTICLES (Record no. 11224)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213144456.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12208 |
| Author | Yasmin Begum, M. |
| 245 ## - TITLE STATEMENT | |
| Title | FORMULATION AND EVALUATION OF DASATINIB LOADED SOLID LIPID NANOPARTICLES |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.10(12) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 14-20p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>Method<br/>s: <br/>SLNs consist of a solid lipid matrix<br/> where the drug <br/>was<br/> incorporated<br/>. Surfactants of GRAS grade were used t<br/>o avoid aggregation and to <br/>stabilize the SLNs. <br/>DST<br/>-SLN<br/>s formulations of varying con<br/>centrations were prepared by high<br/>-speed<br/> homogenization technique and evaluated for <br/>drug excipients compatibility study, poly<br/>-dispersity index, particle size analysis, surface <br/>morphology, zeta potential<br/>, and<br/> drug release features. <br/>The aim of present work wa<br/>s to formulate and <br/>evaluate <br/>Dasatinib<br/> (DST) <br/>loaded solid lipid nanoparticles<br/> (SLNs) <br/>as a potential antic<br/>ancer <br/>drug delivery system<br/> by enhancing its solubility.<br/>Result<br/>s: <br/>It was observed that <br/>DST<br/>-SLNs with optimum<br/> quantities o<br/>f poloxome<br/>r: lecithin ratio showed 88.06% drug release<br/> in 6h<br/> with good <br/>entrapment efficiency of 76.9±0.84 %<br/>. Particle size, Polydispersity<br/> index, zeta potential and drug entrapment efficiency for the optimized <br/>formula<br/>tion was found to be<br/> optimum<br/>. Stability studies <br/>revealed that the entrapment efficiency of the SLN dispersion stored in 4<br/> °C was stable.<br/>Conclusio<br/>n<br/>:<br/>Thus, it can be concluded that <br/>the <br/>formulations<br/> of <br/>DST loaded SLNs<br/> are suitable carriers for improving the <br/>solubility and dissolution <br/>related problems. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12209 |
| Co-Author | Gudipati, Prathyusha Reddy |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/27567/16279 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 13/02/2020 | 2020950 | 13/02/2020 | 13/02/2020 | Articles Abstract Database |