ACUTE AND SUB CHRONIC TOXICITY STUDIES OF PURIFIED WITHANIA SOMNIFERA EXTRACT IN RATS (Record no. 11231)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200213150249.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200213b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12219 |
| Author | Antony, Benny |
| 245 ## - TITLE STATEMENT | |
| Title | ACUTE AND SUB CHRONIC TOXICITY STUDIES OF PURIFIED WITHANIA SOMNIFERA EXTRACT IN RATS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.10(12) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 41-46p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The objective of<br/> the present study was to evaluate the acute and <br/>sub<br/>-chronic (<br/>90 <br/>d; <br/>repeated dose<br/>) toxicity of <br/>Withania somnifera<br/>(ashwagandha) <br/>extract <br/>in rats.<br/>Method<br/>s: <br/>The acute <br/>toxicity was evaluated as per OECD (Organisation for Economic Co<br/>-operation and Development) <br/>guidelines 423. P<br/>urified <br/>ashwagandha extract (PAE) <br/>was fed at 2000 mg/kg body weight (bw) <br/>to overnight fasted <br/>female <br/>rats. <br/>The animals were observed daily <br/>for <br/>clinical <br/>signs of abnormality/mortality. After 1<br/>4 d<br/>, animals were sacrificed and<br/> gross pathologic<br/>al changes were recorded. Sub<br/>-chronic toxicity of PAE was <br/>studied by feeding the extract at 100, 500 and 1000 mg/kg <br/>bw <br/>daily to rats<br/> as per OECD guidelines 408<br/>. After 9<br/>0 d<br/> feeding<br/>, heamatological<br/> and <br/>biochemical parameters <br/>of treated rats <br/>were compared wit<br/>h control animals. Histopathology of all the major organs was also studied.<br/>Result<br/>s: <br/>In the acute toxicity study, no mortality or clinical signs of toxicity were observed in any of the animals at maximum <br/>recommended dose level <br/>of 2000 mg/kg b<br/>w; <br/>therefore the LD50 is<br/>>2000 mg/kg bw in rats. <br/>The repeated administration of PAE<br/> for 9<br/>0 d<br/> in rats at the maximum <br/>dose level of <br/>1000<br/> mg/kg<br/> bw<br/> did not induce any observable toxic <br/>effects,<br/> when compared to its corresponding control animals. <br/>The hematology<br/> and biochemistr<br/>y <br/>profile of treated<br/> rats was similar to control animals <br/>and<br/> difference<br/> was non<br/>-significant (p>0.05). The histopathology of<br/> major organs of <br/>all the control <br/>and treated animals w<br/>as<br/> normal. <br/>In this study<br/> the NOAEL <br/>(No Observed Adverse Effect Level) was calcu<br/>lated as 1000<br/> mg/kg <br/>bw <br/>daily for rats. <br/>Conclusio<br/>n: <br/>The present study clearly indicates that <br/>PAE<br/> does not have any toxic effects in animals at the dose evaluated as evidenced by acute <br/>and <br/>sub chronic <br/>toxicity studies in rats |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12222 |
| Co-Author | Benny, Merina |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/29493/16284 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 13/02/2020 | 2020954 | 13/02/2020 | 13/02/2020 | Articles Abstract Database |