Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose‑adjusted plasma levels of carbamazepine in epileptic patients in South Indian population (Record no. 11467)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200921142941.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200921b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12562 |
| Author | Ganesapandian, Mahalakshmi |
| 245 ## - TITLE STATEMENT | |
| Title | Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose‑adjusted plasma levels of carbamazepine in epileptic patients in South Indian population |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.51(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 384-388p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | AIM: The aim of the study was to compare the dose‑adjusted plasma levels of carbamazepine (CBZ) among expressers and nonexpressers of cytochrome P450 3A5 (CYP3A5)*3 genotypes.SUBJECTS AND METHODS: The study was carried out in 100 epileptic patients who were on CBZ monotherapy. Steady‑state plasma CBZ levels were measured using reverse‑phase high‑performance liquid chromatography method, and genotyping of CYP3A5 was done using real‑time polymerase chain reaction method.RESULTS: Patients inheriting CYP3A5*3/*3 variant (nonexpressers) had an increased plasma concentration of CBZ (4.86 μg/ml) when compared to patients inheriting either CYP3A5*1/*1 or CYP3A5*1/*3 (expressers) (4.3 μg/ml, P = 0.004). Nonexpressers had significantly increased plasma concentrations of CBZ when adjusted for dose and weight when compared to expressers (P < 0.002 and P < 0.001, respectively). The frequency of adverse reactions in expressers and nonexpressers was 12% and 9%, respectively.CONCLUSION: There is a significant influence of CYP3A5*3 genetic polymorphism (6986A>G) on dose‑adjusted plasma levels of CBZ in epileptic patients in the South Indian population. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12563 |
| Co-Author | Ramasamy, Kesavan |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0253-7613 |
| Title | Indian Journal of Pharmacology |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://www.ijp-online.com/temp/IndianJPharmacol516384-3106938_083749.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 21/09/2020 | 2021135 | 21/09/2020 | 21/09/2020 | Articles Abstract Database |