Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification-Desolvation-Crosslinking Technique (Record no. 11483)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200923144050.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12591 |
| Author | Pabbiniddi, Veera Lakshmi |
| 245 ## - TITLE STATEMENT | |
| Title | Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification-Desolvation-Crosslinking Technique |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 663-669p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Recently much emphasis is being laid on the development of microparticles because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. Objective: The objective of the present study is to prepare and evaluate mucoadhesive microparticles of chitosan-gliclazide for oral controlled release. Methods: A new method namely emulsification-desolvation-crosslinking was used for the preparation of chitosan-gliclazide microparticles and the microparticles were evaluated by in vitro and in vivomethods. Results: Spherical chitosan-gliclazide microparticles could be prepared by the emulsification-desolvation-crosslinking method. The method was reproducible with regard to size and size distribution of the microparticles. The chitosan-gliclazide microparticles exhibited good muoadhesive property. Gliclazide release from the chitosan microparticles was slow and extended over longer periods of time and depended on the proportion of core: coat. Gliclazide release from the chitosan microparticles was by diffusion mechanism. Microparticles (F3) prepared using a core: coat ratio of 8:2 gave slow and controlled release of gliclazide over 12 hr similar to that of commercial gliclazide SR tablets. In the in vivo evaluation, the gliclazide microparticles (F3) gave a slower reduction in serum glucose levels and the reduced glucose levels were sustained over longer periods of time. Conclusion: Microparticles (F3) are considered as a promising microparticulate drug delivery system for oral controlled release of gliclazide over 12 hr for b.i.d administration. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12592 |
| Co-Author | Kora Pattabbi, Rama Choudhary |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_4_663.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2020 | 2021151 | 23/09/2020 | 23/09/2020 | Articles Abstract Database |