Formulation and Evaluation of Sodium Alginate and Guar Gum Based Glycyrrhizin Loaded Mucoadhesive Microspheres for Management of Peptic Ulcer (Record no. 15524)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211120141041.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211120b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14693 |
| Author | Harwansh, Ranjit Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation and Evaluation of Sodium Alginate and Guar Gum Based Glycyrrhizin Loaded Mucoadhesive Microspheres for Management of Peptic Ulcer |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.55(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Banagalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 728-737p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Glycyrrhizin (GZ) is a bioactive ingredient of Glycyrrhiza glabra, reported for various therapeutic effects including gastro-protection. It has been associated with low absorption, early elimination, short half-life and poor bioavailability. Objectives: Aim of the current study was to formulate GZ loaded mucoadhesive microspheres by using mucopolymers like sodium alginate and guar gum for the management of peptic ulcer. Methods: Various GZ loaded microspheres (GZ-MS1-3) were prepared by an emulsification-crosslinking technique. These formulations were developed with different proportions of guar gum and sodium alginate. The formulations were characterized and evaluated by various parameters including particle size, zeta potential, entrapment efficiency (% EE), % yield, SEM, FTIR, swelling index, mucoadhesive efficiency, in vitro drug release and in vivo antioxidant activities. Results: Result stated that suitable particle size (50.18 ± 1.15 μm), zeta potential (-31.12 ± 2.16 mV), %EE (92.67 ± 1.91) and % yield (97.45 ± 1.83) was achieved with optimized formulation, GZ-MS1. Significant (***P<0.001) swelling index (0.94 ± 0.04) and mucoadhesive efficiency (95.98 ± 3.62%) was obtained with GZ-MS1. GZ-MS1 showed maximum drug release profile (94.57 ± 4.03 %) in simulated gastric fluid (SGF, pH 1.2) at 37 ± 0.5°C for 24 h. FTIR study confirmed that there was no interaction observed between GZ and excipients. Conclusion: Sustained release profile of the optimized formulation was achieved due to significant mucoadhesive efficiency of the sodium alginate and guar gum. Thus, the mucoadhesive microspheres of GZ would be an effective strategy for the management of peptic ulcer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14694 |
| Co-Author | Rohitas Deshmukh |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-3-728.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 20/11/2021 | 2021-2022329 | 20/11/2021 | 20/11/2021 | Articles Abstract Database |