Antithrombotic Potential of Red Allium cepa and Angelica gigas Nakai (Record no. 15536)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211122120618.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211122b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14717 |
| Author | Lee, Jin Young |
| 245 ## - TITLE STATEMENT | |
| Title | Antithrombotic Potential of Red Allium cepa and Angelica gigas Nakai |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.55(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Banagalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 837-845p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Red Allium cepa and Angelica gigas Nakai is widely used in oriental medicine and also has various physiological activities. The main components of two substances will have potential benefits to blood flow improvement. Objectives: This study evaluated the cell viability and antioxidant effects of Red Allium cepa extract, Angelica gigas Nakai extract and their mixture and observed anticoagulation activity and antiplatelet aggregation activity. Methods: Red Allium cepa was bioconverted through the use of the Bacillus subtilis KJ-3 (BS3) strain after ethanol extraction (Red-BCQ). Angelica gigas Nakai extract (Agnex) contains a large amount of coumarins such as decursin and decursinol angelate (D/DA). Here, we observed antioxidant and antithrombotic effects after treatment with Red-BCQ, Agnex and mixture of these two compounds. Results: The quercetin content of Red-BCQ increased by about 7.4-fold after bioconversion. A 1 mg portion of Agnex contained 0.4146 mg of D and 0.3659 mg of DA. Red-BCQ and Agnex exerted strong antioxidant activities due to their high polyphenol and flavonoid content. In our study, Red-BCQ and Agnex exhibit beneficial effects to external coagulation pathways by significantly expanding aPTT. However, a combination of Red-BCQ and Agnex did not exert any synergistic effect on anti-coagulation activity. Additionally, our results concerning platelet aggregation inhibitory effects revealed that these effects increased by treatment with Agnex alone or in combination with Red-BCQ. Conclusion: Further research is required to clarify the underlying mechanism. However, Red-BCQ and Agnex are considered to possess antioxidant effects either alone or as a mixture and also exert antithrombotic effects. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14718 |
| Co-Author | Kang, Jae Seon |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-3-837.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/11/2021 | 2021-2022341 | 22/11/2021 | 22/11/2021 | Articles Abstract Database |