Formulation and Characterization of Chitosan Microparticulate System Using Central Composite Design for the Drug: Lafutidine (Record no. 15552)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211123100139.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211123b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 11968 |
| Author | Sunil Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation and Characterization of Chitosan Microparticulate System Using Central Composite Design for the Drug: Lafutidine |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.55(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Banaglore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 354-362p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: To formulate a Micro particulate system using central composite design to remain in the stomach for prolonged time and used for Gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation. Micro particulate system were evaluated for micro meritic study, percentage yield, drug entrapment efficiency, in-vitro buoyancy, surface morphology, in-vitro drug release, in-vivo floating study and stability studies. Results: The micro meritic parameters of floating microspheres were found to be within the acceptable limits. The particle size of microspheres was found to be in the range 3.43–15.38 μm. The entrapment efficiency was found to be in the range of 72.02–95.02%. The floating microspheres were spherical in shape with distinct pores, slightly rough surface when observed under scanning electron microscopy. The percentage yield was found to be in the range of 68–89%. The in-vitro buoyancy was found to be in the range of 55.67–92.55% and a total buoyancy time of more than 10 h. The in-vitro dissolution studies showed a cumulative % release in the range of 77.67–95.41%. The optimized formulation F4 was floating in rat stomach for almost 8 h. All the formulations followed Korsemeyer- Peppas kinetics indicating drug release by non-fickian release mechanism. The stability studies showed that floating microspheres were stable at 40 ± 2°C. Conclusion: The optimized formulation showed good floating for 12 h in stomach of rat. The formulation was able to treat the alcohol induced ulcer and also found good stability. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14747 |
| Co-Author | Goyal, Naveen |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-354.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/11/2021 | 2021-2022357 | 23/11/2021 | 23/11/2021 | Articles Abstract Database |