Stability Indicating Assay Method Development and Validation for Simultaneous Estimation of Ofloxacin and Ornidazole by RP-HPLC in Bulk: An Application to Tablet Formulation and Dissolution Studies (Record no. 15583)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211124103657.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211124b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14795 |
| Author | D’Souza, Kevita |
| 245 ## - TITLE STATEMENT | |
| Title | Stability Indicating Assay Method Development and Validation for Simultaneous Estimation of Ofloxacin and Ornidazole by RP-HPLC in Bulk: An Application to Tablet Formulation and Dissolution Studies |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.55(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Banaglore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 607-613p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The present article focuses on development of sensitive, simple, precise, accurate and inexpensive stability indicating assay method for the simultaneous estimation of Ofloxacin and Ornidazole in bulk was established using RPHPLC. Materials and Methods: The separation was done with C18 Phenomenex Hyperclone BDS column (250×4.6mm, 5μ) at a temperature of 25°C using a mobile phase of acetonitrile: pH 5.8 ammonium acetate buffer of ratio 25:75 with a flow rate of 1ml/min. The detection was done at 293nm and 311nm and the retention time for Ofloxacin and Ornidazole was 4.278 min and 6.750 m respectively. Results: The method was seen to be linear over the range of 2-16μg/ml for both drugs. The method was precise and robust with LOD of 0.331 and 0.360 and LOQ of 1.005 μg/ml and 1.092 μg/ml for Ofloxacin and Ornidazole respectively. The drugs were subjected to stress conditions in acidic, alkaline, oxidative, thermal and photolytic conditions. Conclusion: The method for this simultaneous estimation was found to be accurate, precise, fast and simple with a run time within 8 min. This method developed was applied with success for the assay and dissolution studies in tablet formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14797 |
| Co-Author | Alisha Syeda |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-607.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/11/2021 | 2021-2022384 | 24/11/2021 | 24/11/2021 | Articles Abstract Database |