Rheumatoid arthritis: pathophysiology, treatment and improved efficacy of targeted treatment using novel herbal therapeutics formulations (Record no. 15642)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211220143037.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211220b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14869 |
| Author | Singh, Bikram |
| 245 ## - TITLE STATEMENT | |
| Title | Rheumatoid arthritis: pathophysiology, treatment and improved efficacy of targeted treatment using novel herbal therapeutics formulations |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(3), Jul-Sept |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 208-216p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that leads to synovial inflammation,<br/>destruction of articular cartilage, bone erosion, deformities, accompanied by pain, swelling, and stiffness, most<br/>commonly in limbs. The pathophysiology elaborates on the role of T-helper (Th1) cells secreted in response to<br/>interleukin-1 (IL-1) and 12, thus producing pro-inflammatory ILs whereas Th2 cells activated by IL-4 secretes<br/>anti-inflammatory cytokines (IL-4, 5, 10 and 13). A neutralization of endogenous anti-inflammatory cytokines<br/>mainly IL-10 by the production of anti-IL-10 monoclonal antibodies, results in the downregulation of antiinflammatory<br/>cytokines which lead to more severe collagen-induced arthritis. Conventional treatment for RA<br/>includes non-steroidal anti-inflammatory drugs, glucocorticoids, non-biologics, and biological disease-modifying<br/>anti-rheumatic drugs, a conjugate of the humanized monoclonal antibody, dendritic cells, etc. Although,<br/>conventional therapy and newer treatments are effective but suffer from several limitations like serious adverse<br/>effects, high cost, and invasive intervention. The information regarding disease, pathophysiology, treatment, and<br/>novel interventions was collected through vigorous literature search from authentic search engines, books and<br/>journals using relevant keywords. Novel herbal therapies using phytochemicals of Curcuma longa, Zingiber<br/>officinale, Glycyrrhiza glabra, Withania somnifera, Tripterygium wilfordii, Boswellia serrata, Camellia sinensis,<br/>Tanacetum parthenium, Commiphora wightii, Mukul, Plumbago zeylanica through their promising novel drug<br/>delivery systems like microspheres, transdermal patches, ethosomes, liposomes, and phytosomes. have shown<br/>promising response and efficacy via well-defined immune mechanism along with their easy accessibility, mild<br/>or negligible adverse effects, thus gaining the edge over conventional and invasive therapies for RA. This review<br/>indicates that there is a need to study these novel formulations, extensively on preclinical and clinical levels and<br/>develop these herbal therapies as a promising alternative to conventional therapies for the treatment of RA. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14870 |
| Co-Author | Singh, Maninder |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14871 |
| Co-Author | Kaur, Arshvir |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| Title | International journal of green pharmacy |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 20/12/2021 | 2021-2022460 | 20/12/2021 | 20/12/2021 | Articles Abstract Database |