Design, in silico analysis, synthesis, and evaluation of novel benzofused nitrogen-containing heterocyclic N-substituted mercaptobenzimidazole derivatives as potential antimicrobial agent (Record no. 15644)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211220145223.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211220b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14879 |
| Author | Patil, Tejaswini D. |
| 245 ## - TITLE STATEMENT | |
| Title | Design, in silico analysis, synthesis, and evaluation of novel benzofused nitrogen-containing heterocyclic N-substituted mercaptobenzimidazole derivatives as potential antimicrobial agent |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15 (3), Jul-Sept |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 226-237p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: There is an urgent need for buy soma online overnight delivery the development of novel antimicrobial drugs due to the rapid<br/>development of antimicrobial drug resistance. Benzimidazole containing mercapto group at 2-position is attractive<br/>nucleus for modification with wider pharmacological activities. Objective: The aim of this study is to design<br/>benzofused nitrogen-containing heterocyclic derivatives of mercaptobenzimidazole using molecular docking,<br/>synthesis of active derivative and evaluation as potential antimicrobial agent. Materials and Methods: Using<br/>an effective procedure, N-substituted mercaptobenzimidazole derivatives were synthesized based on the<br/>literature review. The antimicrobial activity of all synthesized compounds was tested against four different<br/>organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. Molecular<br/>docking of mercaptobenzimidazole derivatives against DNA gyrase subunit B Protein Data Bank (PDB): 5l3j and<br/>S. aureus tyrosyl-tRNA synthetase PDB: 1jij was performed using docking protocol. The compound binds to buy soma online usa the<br/>active site of DNA gyrase subunit B (1KZN) in a docking study, indicating that it may have antimicrobial activity.<br/>Conclusion: The compounds MB3 and MB5 have antimicrobial capacity, according to the findings of this report.<br/>MB4 has the high activity against C. albicans. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14880 |
| Co-Author | Amrutkar, Sunil V. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| Title | International journal of green pharmacy |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://greenpharmacy.info/index.php/ijgp/article/view/3149 |
| Link text | Full Text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 20/12/2021 | 2021-2022462 | 20/12/2021 | 20/12/2021 | Articles Abstract Database |