In silico molecular docking analysis of selected phytoconstituents from Psydrax dicoccos (Gaertn.) against Parkinson’s disease (Record no. 15657)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211221104844.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14902 |
| Author | Pasumarthy, Sree Mahalakshmi |
| 245 ## - TITLE STATEMENT | |
| Title | In silico molecular docking analysis of selected phytoconstituents from Psydrax dicoccos (Gaertn.) against Parkinson’s disease |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(3), Jul-Sept. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mandsaur |
| Name of publisher, distributor, etc. | B.R. Nahata Smriti Sansthan |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 278-287p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Parkinson’s disease is a major neurodegenerative disorder that occurs due to the loss of<br/>dopamine in Substantianigra pars compacta. The disease can be treated by inhibiting α-synuclein protein tramadol cheap,<br/>monoamine oxidase-B (MAO-B), a neurotransmitter (dopamine) pack in the synaptic vesicle, and inflammation.<br/>Material and Methods: Six phytoconstituents were identified from a plant Psydrax dicoccos of the family,<br/>Rubiaceae. Sequesterpenes and coumarins are found in this plant which is a source of neuroprotection. Ligands<br/>were analyzed for docking analysis using Autodock Vina software against the targets (α-synuclein, heat shock<br/>protein-70, matrix metalloprotease-3, synaptic vesicle protein, nitric oxide synthase, cannabinoid receptor type-<br/>2, MAO-B, and Nrf2 [nuclear factor erythroid 2-related factor-2]) of Parkinson’s disease and compared with<br/>standards. Multiple targets were selected due to complexity of Parkinson’s disease. It has a complex structure and<br/>a variety of molecular proteins affects the desired effect of the drug. Docking interactions are identified by Biovia<br/>Discovery Studio Visualizer 2021. In silico pharmacokinetics (ADME) was analyzed by Swiss ADME, ADMET<br/>lab. The effectiveness of the ligands was predicted by Molinspiration studies. Result: The results showed that that<br/>the anti-Parkinson compounds tramadol 100 mg activity was due to their action on multiple targets. Examining all the parameters,<br/>it shows that P. dicoccos has the potential to cure Parkinson’s disease. Conclusion: In this study, it was concluded<br/>that all six ligands scored well compared to those of standards. All ligands exhibited good pharmacokinetics low<br/>solubility, optimal (CaCo2 permeability, volume of distribution, and plasma protein binding), and BBB tolerant . |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14897 |
| Co-Author | Thakur, Santh Rani |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://greenpharmacy.info/index.php/ijgp/article/view/3156 |
| Link text | Full text |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 21/12/2021 | 2021-2022475 | 21/12/2021 | 21/12/2021 | Articles Abstract Database |