Revisiting Therapeutic Potentials of Ethanolic Extract of Curcuma longa L. rhizomes to Evaluate wound Healing Progression upon Topical Application of its Ointment (Record no. 15677)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211221152933.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211221b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14942 |
| Author | Adhikary, Tathagata |
| 245 ## - TITLE STATEMENT | |
| Title | Revisiting Therapeutic Potentials of Ethanolic Extract of Curcuma longa L. rhizomes to Evaluate wound Healing Progression upon Topical Application of its Ointment |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.55(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 174-183p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and Aim: The goodness of turmeric is claimed traditionally but providing proper scientific data will not only support the statements making it more evident but will also search for possible ways to enhance its potential. The present study aims to extract the bioactive components from turmeric rhizomes to appraise its ability as a therapeutic agent. Methodology: Ethanolic extract and its doses were prepared for antioxidant and cytotoxicity assay. In-vivo study of wound healing activity of turmeric extract in the form of an ointment was evaluated upon its topical application in incision and excision wound models. The excised tissue samples were subjected to hematoxylin and eosin staining and content estimation of collagen biomarkers namely hydroxyproline, hexosamine and hexuronic acid. Results: DPPH assay showed the significant antioxidant activity of the extract with an IC50 value of 37.09 ± 2.17μg/ml while MTT assay revealed an IC50 value of 96.2± 2.48 μg/ml against human breast cancer cell line MCF-7. In the incision and excision models, % breaking strength of the wound and wound contraction rate in turmeric ointment treated mice w.r.t standard drug-treated mice are 109.28 % and 80.5 % while untreated mice exhibited a value of 77.75% and 52.74% respectively. Qualitative evaluation of the wound healing progression is depicted by the histopathological study of tissues. Indirect assessment of collagen content in tissues by quantitative estimation of collagen biomarkers aids to predict the progress of wound healing as their occurrence in increased amount confirmed the wound healing potential of turmeric and the prepared ointment base. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14943 |
| Co-Author | Chowdhury, Mobaswar Hossain |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_174.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 21/12/2021 | 2021-2022497 | 21/12/2021 | 21/12/2021 | Articles Abstract Database |