Statistical optimization and evaluation of a multi release unit bilayer tablet of rizatriptan benzoate (Record no. 15807)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211229102347.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211229b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15182 |
| Author | Reddy, Kavya Handenahalli Ramakrishna |
| 245 ## - TITLE STATEMENT | |
| Title | Statistical optimization and evaluation of a multi release unit bilayer tablet of rizatriptan benzoate |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 52-59p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Migraine, a neurological condition is often associated with intense, throbbing, crippling headaches for<br/>hours to days. Rizatriptan benzoate has established its potential in controlling the symptoms of migraine.<br/>The present study aims to formulate a bilayer tablet of rizatriptan with multi release unit matrix embedded<br/>in the sustained layer to achieve a pulsatile release of the drug to control the various phases of migraine.<br/>A preliminary study on four matrices-F1, F2, F3 and F4 with different proportion of carnauba wax and<br/>ethyl cellulose was done to evaluate the release pattern of rizatriptan in fasted state simulated intestinal<br/>fluid at pH 6.5. A simplex lattice design was used to find out the optimized ratio of the matrices to control<br/>the dissolution of rizatriptan benzoate in a predetermined fashion at different hour’s intervals. The release<br/>profile was optimized with a blend of three different formulations (F1:F2:F3=0.53:0.24:0.23). Statistical<br/>analysis revealed that the percentage error between the predicted and optimum blend was less than 5 %.<br/>The immediate release layer was formulated with direct compression method using super disintegrants.<br/>The evaluation of bilayer tablet was done for hardness, weight variation, friability, uniformity of content<br/>and percentage release. The tablet met the criteria of pharmacopoeial requirements. The bilayer tablet<br/>of rizatriptan benzoate could able to release the drug instantly as comparable with marketed immediate<br/>release tablet of rizatriptan benzoate and could also prolong the release for 24 h. The accelerated stability<br/>study also showed the tablets could retain their property at variable temperature and humidity. Therefore,<br/>it can be concluded that the bilayer tablet of rizatriptan benzoate embedded in a wax polymer multi<br/>release unit matrix has a potential to deliver the drug at a predetermined rate for the effective control of<br/>migrainee. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14759 |
| Co-Author | Bhattacharyya, Sayani |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/statistical-optimization-and-evaluation-of-a-multi-release-unit-bilayer-tablet-of-rizatriptan-benzoate.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/12/2021 | 2021-2022624 | 29/12/2021 | 29/12/2021 | Articles Abstract Database |