Bioactive metabolites of aspergillus neoniger, an endophyte of the medicinal plant ficus carica (Record no. 15814)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211229114740.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211229b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15193 |
| Author | Abdou, Randa |
| 245 ## - TITLE STATEMENT | |
| Title | Bioactive metabolites of aspergillus neoniger, an endophyte of the medicinal plant ficus carica |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 101-109p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Endophytes are considered as a rich source of bioactive natural products. Many plants have not been<br/>investigated for their endophytic content yet, such as the medicinal plant Ficus carica . Recent studies<br/>confirmed antimicrobial and anticancer activities for the plant extract. To find out if its endophytes<br/>contribute to its reported activities, the bioactive endophyte Aspergillus neoniger was selected for<br/>investigation of its metabolites since it exerted antimicrobial and anticancer activities in preliminary<br/>screening assays. The fungal extract was subjected to bioactivity guided chromatographic fractionation for<br/>isolation of its bioactive metabolites. This resulted in the identification of four aurasperones (asperpyrone<br/>D, aurasperone D, dianhydroaurasperone C, aurasperone A) through spectroscopic analysis. Aurasperone<br/>D and asperpyrone D were found to be cytotoxic against human cervical cancer cells (50 % cytotoxic<br/>concentration=4.4 μg ml -1 and 3.0 μg ml -1 respectively). Aurasperone D exerted strong antiproliferative<br/>effect against human immortal erythroleukaemia cells 562 and human umbilical vein endothelial cells<br/>(concentration at which 50 % growth inhibition achieved was 5.3 and 4.7μg ml-1) as well as asperpyrone D<br/>(concentration at which 50 % growth inhibition achieved was 4.9 and 5.4μg ml-1). Dianhydroaurasperone<br/>C and aurasperone A, on the contrary, showed weak cytotoxic and antiproliferative effects. All compounds<br/>were tested for antimicrobial activity against several test strains including the plant pathogen Fusarium<br/>oxysporum. Results revealed that aurasperone D and asperpyrone D to be most active which suggests<br/>potential protective role of this endophyte on its host plant. These results suggest possible partial<br/>contribution of Aspergillus neoniger to the reported activity of the host plant. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15194 |
| Co-Author | Alqahtani, Alaa M. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/bioactive-metabolites-of-emaspergillus-neonigerem-an-endophyte-of-the-medicinal-plant-emficus-caricaem.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/12/2021 | 2021-2022631 | 29/12/2021 | 29/12/2021 | Articles Abstract Database |