Evaluation of anticancer activity of Clerodendrum viscosum leaves against breast carcinoma (Record no. 15860)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211231105444.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211231b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15276 |
| Author | Shendge, Anil Khushalrao |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of anticancer activity of Clerodendrum viscosum leaves against breast carcinoma |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(5), Sep-Oct |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 377-383p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | INTRODUCTION: The use of natural resources as medicines for cancer therapies has been described<br/>throughout history in the form of traditional medicines. However, many resources are still unidentified<br/>for their potent biological activities.Clerodendrum viscosum is a hill glory bower reported as a remedy<br/>against oxidative stress, skin diseases, and intestinal infections.<br/>MATERIALS AND METHODS: We have collected the C. viscosum leaves and used for the<br/>preparation of 70% methanolic extract (CVLME). Then, CVLME has been confirmed for anticancer<br/>properties on various cancer cell lines by evaluating cytotoxicity, cell cycle analysis, induction of<br/>ROS and apoptosis, and nuclear fragmentation. Further, the phytochemical analysis of CVLME was<br/>evaluated through high‑performance liquid chromatography.<br/>RESULTS: Cell proliferation assay revealed the selective cytotoxicity of CVLME against breast<br/>cancer cell line (MCF‑7). The FACS‑based cell cycle analysis showed increased subG1 (apoptosis)<br/>population dose dependently. Further, the apoptosis‑inducing effect of CVLME was confirmed by<br/>annexin staining. Flow cytometry and confocal microscopy revealed the selective ROS generation<br/>upon CVLME treatment. The confocal‑based morphological study also revealed condensed and<br/>fragmented nuclear structure in CVLME‑treated MCF‑7 cells. Phytochemical investigations further<br/>indicated the presence of tannic acid, catechin, rutin, and reserpine which might be the reason for<br/>the anticancer activity of CVLME.<br/>CONCLUSION: The above‑combined results revealed the anticancer effect of CVLME, which may<br/>be due to the selective induction of ROS in breast carcinoma |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15277 |
| Co-Author | Basu, Tapasree |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| International Standard Serial Number | 0253-7613 |
| Title | Indian Journal of Pharmacology |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol535377-1925666_052056.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 31/12/2021 | 2021-2022677 | 31/12/2021 | 31/12/2021 | Articles Abstract Database |