Antidiabetic activity of Commiphora mukul and Phyllanthus emblica and Computational analysis for the identification of active principles with dipeptidyl peptidase IV inhibitory activity (Record no. 15861)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211231110228.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211231b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15278 |
| Author | Mohanty, Ipseeta Ray |
| 245 ## - TITLE STATEMENT | |
| Title | Antidiabetic activity of Commiphora mukul and Phyllanthus emblica and Computational analysis for the identification of active principles with dipeptidyl peptidase IV inhibitory activity |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(5), Sep-Oct |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 384-387p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The medicinal plants may serve as natural alternatives to synthetic antidiabetic medications such<br/>as dipeptidyl peptidase‑IV (DPP‑IV) inhibitors, which are commonly prescribed in clinical practise.<br/>The medicinal plants: Commiphora mukul and Phyllanthus emblica have considerable DPP‑IV<br/>inhibitory efficacy, according to our findings. The present study is an extension of the previous<br/>study conducted in our laboratory and was designed to confirm the antidiabetic effects of C. mukul<br/>and P. emblica in the streptozotocin diabetes model and elucidate the active principles responsible<br/>for DPP‑IV inhibition. C. mukul (Guggul) and P. emblica (Amla) have the ability to inhibit DPP‑IV<br/>and have anti‑diabetic properties in a Type 2 diabetes mellitus experimental model. The binding<br/>sites and affinity of the active principles of C. mukul (Gluggusterone E, Gluggusterone Z) and<br/>P. emblica (Pzrogallol, beta‑glucogallin, and gallic acid) responsible for DPP‑IV enzyme inhibition<br/>were identified using in silico studies and compared to Vildagliptin, a synthetic DPP‑IV inhibitor. The<br/>Vildagliptin and therapy groups had significantly lower glycated hemoglobin and DPP‑IV levels. The<br/>anti‑diabetic effect of C. mukul and P. emblica is due to their DPP‑IV inhibitory action. The DPP‑IV<br/>inhibitory action of Gluggusterone E, Gluggusterone Z, and beta‑Glucogallin was found to be superior<br/>to Vildagliptin in docking tests. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15279 |
| Co-Author | Selvaa Kumar, C. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0253-7613 |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol535384-1955428_052554.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 31/12/2021 | 2021-2022678 | 31/12/2021 | 31/12/2021 | Articles Abstract Database |