Comparative effectiveness of metoprolol, ivabradine, and its combination in the management of inappropriate sinus tachycardia in coronary artery bypass graft patients (Record no. 15866)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220101093341.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220101b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15288 |
| Author | Bhatt, Parloop |
| 245 ## - TITLE STATEMENT | |
| Title | Comparative effectiveness of metoprolol, ivabradine, and its combination in the management of inappropriate sinus tachycardia in coronary artery bypass graft patients |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(4), July-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 264-269p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | BACKGROUND: Inappropriate sinus tachycardia (IST) is an arrhythmic complication observed<br/>after coronary artery bypass graft (CABG) surgery which left untreated, commonly increases<br/>chances of postoperative stroke. The primary study objective was comparing effectiveness of beta<br/>blocker‑metoprolol; a specific If blocker‑ivabradine and its combination in patients who develop IST<br/>as a complication following CABG.<br/>MATERIALS AND METHODS:An open‑labeled, investigator initiated, clinical study was conducted<br/>on 150 patients who developed IST (heart rate [HR] >100 beats/min) following elective CABG surgery.<br/>The patients were randomized into three treatment groups. Group I – received ivabradine (5 mg),<br/>Group II – metoprolol (25 mg), and Group III – ivabradine (5 mg) and metoprolol (25 mg). Treatment<br/>was given orally, twice a day for 7 days in all the three groups postoperatively. Primary endpoints<br/>were comparative effectiveness in HR and blood pressure reduction following treatment.<br/>RESULTS: IST was diagnosed by an electrocardiogram (12‑lead) considering morphological features<br/>of P‑wave and with 32% increase from baseline HR in all the three groups. Compared to IST arrthymic<br/>rate, HR was reduced in all groups following respective treatment (P = 0.05). Reduction in HR was<br/>significant (P < 0.05) in combination group followed by ivabradine which was significantly greater than<br/>metoprolol treated group. None of the treatments clinically changed the systolic, diastolic and mean<br/>blood pressure till discharge. No surgery/treatment‑related complications were observed in any groups.<br/>CONCLUSION: Ivabradine stands as a pharmacological option for controlling HR and rhythm without<br/>associated side effects in postoperative CABG patients with IST |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15289 |
| Co-Author | Bhavsar, Niren |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://ijp-online.com/temp/IndianJPharmacol534264-1426397_035743.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 01/01/2022 | 2022-0001 | 01/01/2022 | 01/01/2022 | Articles Abstract Database |