Current concepts and molecular mechanisms in pharmacogenetics of essential hypertension (Record no. 15872)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220101103526.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220101b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15300 |
| Author | Farhana Rahman |
| 245 ## - TITLE STATEMENT | |
| Title | Current concepts and molecular mechanisms in pharmacogenetics of essential hypertension |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(4), July-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 301-309p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hypertension is a leading age‑related disease in our society and if left untreated, leads to fatal<br/>cardiovascular complications. The prevalence of hypertension has increased and becomes a<br/>significant global health economic burden, particularly in lower‑income societies. Many loci associated<br/>with blood pressure and hypertension have been reported by genome‑wide association studies that<br/>provided potential targets for pharmacotherapy. Pharmacogenetic research had shown interindividual<br/>variations in drug efficacy, safety, and tolerability. This could be due to genetic polymorphisms in<br/>the pharmacokinetics (genes involved in a transporter, plasma protein binding, and metabolism)<br/>or pharmacodynamic pathway (receptors, ion channels, enzymes). Pharmacogenetics promises<br/>great hope toward targeted therapy, but challenges remain in implementing pharmacogenetic aided<br/>antihypertensive therapy in clinical practice. Using various databases, we analyzed the underlying<br/>mechanisms between the candidate gene polymorphisms and antihypertensive drug interactions and<br/>the challenges of implementing precision medicine. We review the emergence of pharmacogenetics<br/>and its relevance to clinical pharmacological practice. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15301 |
| Co-Author | Muthaiah, Nagasundaram |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://ijp-online.com/temp/IndianJPharmacol534301-1658395_043623.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 01/01/2022 | 2022-0007 | 01/01/2022 | 01/01/2022 | Articles Abstract Database |