Bergenia ciliata: isolation of active flavonoids, gc-ms analysis, adme study and inhibition activity of oxalate synthesizing enzymes (Record no. 15999)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220119122856.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220119b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15502 |
| Author | Gophane, Shweta R. |
| 245 ## - TITLE STATEMENT | |
| Title | Bergenia ciliata: isolation of active flavonoids, gc-ms analysis, adme study and inhibition activity of oxalate synthesizing enzymes |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.13(11) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bhopal |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 34-46p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: Bergenia ciliata (family-Saxifragaceae) is a well-known herb for kidney stone. The main objective of the study was the identification of flavonoids along with ADME profile. Another supportive objective was to check inhibition of enzymes which perform active role in oxalate synthesis.<br/><br/>Methods: The hydromethanolic extract was fractionated by liquid-liquid extraction to obtain ethyl acetate and ethyl ether fractions. The chemical structures of the purified compounds were identified by gas chromatography-mass spectrometry.<br/><br/>Results: A total of 12 volatile chemical compounds belonging to hydrocarbons, esters, alcohols, fatty acids, ketones, etc. were identified and characterized in ethyl acetate fraction through GC-MS analysis Fractions enriched in flavonoids showed glycolate oxidase and lactate dehydrogenase enzyme inhibition with IC50 value (µg/ml) 65.76 and 69.84 respectively. The kinetic behaviour of the extracts that inhibit the Glycolate oxidase and Lactate dehydrogenase activity was determined by the Lineweaver-Burk plot. The mode of inhibition of the studied plant extract was type of a non-competitive inhibition. ADMET screening of compounds successfully passed all the parameters of screening.<br/><br/>Conclusion: On the basis of the results, it was found that Bergenia ciliata (rhizome) may serve as a novel and rich source of therapeutic compounds and it can be further explored for urolithiasis treatment purposes. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 653 ## - Keywords | |
| Keywords | Flavonoids |
| 653 ## - Keywords | |
| Keywords | Lactate dehydrogenase |
| 653 ## - Keywords | |
| Keywords | Inhibition |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15503 |
| Co-Author | Jadhao, Sagar R. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15504 |
| Co-Author | Jamdhade, Preeti B. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/42127/25556 |
| Link text | Full Article |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Circulation | School of Pharmacy | School of Pharmacy | Archieval Section | 19/01/2022 | 2022-0128 | 19/01/2022 | 19/01/2022 | Articles Abstract Database |