Determination of in vitro human whole blood‑to‑plasma ratio of THJ‑018 utilizing gas chromatography–Mass spectrometry (Record no. 16877)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220624100104.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220624b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16772 |
| Author | Sachil Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Determination of in vitro human whole blood‑to‑plasma ratio of THJ‑018 utilizing gas chromatography–Mass spectrometry |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 13-18p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | OBJECTIVES: This study was aimed to determine in vitro human whole blood‑to‑plasma ratio (KWB/P)<br/>of THJ‑018 by gas chromatography/mass spectrometry (GC/MS).<br/>MATERIALS AND METHODS: The samples (human blood) were sprayed with THJ‑018 and an<br/>internal standard and extracted using solid‑phase extraction. THJ‑018 was determined in the final<br/>extracts by GC/MS.<br/>RESULTS: The value for K WB/P was 1.56 (1.38–1.81), and red blood cell partitioning was<br/>1.01 (1.01–1.02). The distribution of THJ‑018 between whole blood and plasma was observed to<br/>be affected by temperature.<br/>CONCLUSION: The data analysis supports the proposition that the ratio of the plasma to whole blood<br/>concentrations (1.56) is a suitable parameter characterizing THJ‑018 distribution in whole blood. For<br/>toxicological analysis, it would be best to refrain from converting any drug concentration measured<br/>in whole blood to that anticipated in plasma or serum; however, toxic and therapeutic concentrations<br/>should be determined for the individual specimens collected. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16773 |
| Co-Author | Alkhibery, Remal Nahar Khleel |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol53113-1605548_042735.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/06/2022 | 2022-0854 | 24/06/2022 | 24/06/2022 | Articles Abstract Database |