Modulation of liver p‑glycoprotien expression may contribute to gossypin protection against methotrexate‑induced hepatotoxicity (Record no. 16879)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220624101657.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220624b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16776 |
| Author | Mohamed, Mervat |
| 245 ## - TITLE STATEMENT | |
| Title | Modulation of liver p‑glycoprotien expression may contribute to gossypin protection against methotrexate‑induced hepatotoxicity |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 25-30p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | OBJECTIVES: Methotrexate (MTX) is a broadly used anticancer. Its major side effect is hepatotoxicity.<br/>Gossypin is a flavonoid has a hepatoprotective effect as well as antitumor property. The study aimed<br/>at inspecting the protective effect of gossypin against MTX hepatotoxicity.<br/>MATERIALS AND METHODS: Twenty‑four adult male rats arranged into four groups (six rats each):<br/>control, gossypin control, MTX, and MTX+ gossypin. Animals were orally administered gossypin<br/>at 10 mg kg‑1 day‑1 for 7 days. MTX was injected i.p. (20 mg/kg‑1 once) on 5th day. Liver enzyme<br/>and oxidative stress markers were assessed. BAX, transforming growth factor‑beta (TGF‑β) gene<br/>expressions, and P‑glycoprotein (P‑gp) were assessed. The histopathological study as well as the<br/>immunohistochemical study for hepatic caspase 3 and nuclear factor kappa‑B (NFκ‑B) was done.<br/>RESULTS: MTX produced a significant increase of liver enzymes and distortion of hepatic architecture<br/>alongside with increased the hepatic collagen content. MTX administration significantly increased<br/>the oxidative stress markers and upregulated the pro‑apoptotic BAX and the pro‑fibrogenic TGF‑β.<br/>MTX increased caspase 3 and NFκ‑B expression, while diminished the expression of P‑gp. Gossypin<br/>pretreatment improved the previous parameters, restored the normal hepatic architecture, reduced<br/>the hepatic fibrosis, and regained nearly normal expressions for BAX, TGF‑β, caspase 3, and NFκ‑B.<br/>Gossypin caused more reduction in P‑gp hepatic expression.<br/>CONCLUSIONS: Gossypin may be a valuable adjuvant therapy that protects the liver against<br/>MTX toxicity through antioxidant, anti‑inflammatory, antiapoptotic mechanisms, and mediated P‑gp<br/>expression reduction. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16777 |
| Co-Author | El Sheikh, Azza Kamal |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol53125-1694899_044228.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/06/2022 | 2022-0856 | 24/06/2022 | 24/06/2022 | Articles Abstract Database |