Construction of time‑response curve for neuronal and vascular endothelial dysfunction in ovariectomized rats (Record no. 16880)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220624103106.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220624b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16778 |
| Author | Bansal, Seema |
| 245 ## - TITLE STATEMENT | |
| Title | Construction of time‑response curve for neuronal and vascular endothelial dysfunction in ovariectomized rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 31-38p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | BACKGROUND: Studies have shown that there is a critical time period to start hormone therapy<br/>after the loss of ovarian function during menopause. The length of estrogen deprivation may evolve<br/>different pathophysiological manifestations.<br/>OBJECTIVE: The aim of the present study was to investigate behavioral, biochemical, and<br/>molecular alterations at different time points after surgical menopause with an aim and identify<br/>various pathophysiological targets to exploit “window of opportunity” and to design newer therapeutic<br/>modalities for menopause‑associated neurobehavioral and vascular deficits.<br/>MATERIALS AND METHODS: Bilateral ovariectomy was performed to induce surgical menopause<br/>and estrogen deficiency state. Menopause‑associated neuronal and vascular dysfunctions were<br/>noted after 1, 2, and 3 months of the study.<br/>RESULTS: Neuronal and vascular endothelial dysfunction post ovariectomy revealed that behavioral,<br/>biochemical, molecular, and vascular endothelial dysfunction appeared after 1 month of ovariectomy<br/>except hyperglycemia, which occurs after 3 months.<br/>CONCLUSIONS: Time‑response studies measuring behavioral, biochemical, and molecular markers<br/>at various time points after ovariectomy reveal that there is a fast onset of neuronal and vascular<br/>complications, but the duration of insulin resistance is a relatively late phenomenon. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16779 |
| Co-Author | Chopra, Kanwaljit |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol53131-1732562_044845.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/06/2022 | 2022-0857 | 24/06/2022 | 24/06/2022 | Articles Abstract Database |