Potential ameliorative effect ofCynodon dactylon (L.) pers on scopolamine‑induced amnesia in rats: Restoration of cholinergic and antioxidant pathways (Record no. 16882)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220624104057.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220624b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16782 |
| Author | Pattanashetti, Laxmi A. |
| 245 ## - TITLE STATEMENT | |
| Title | Potential ameliorative effect ofCynodon dactylon (L.) pers on scopolamine‑induced amnesia in rats: Restoration of cholinergic and antioxidant pathways |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.53(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 50-59p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | AIM: The present study explored Cynodon dactylon hydro‑ethanolic extract (CDE) effect on<br/>scopolamine‑induced amnesic rats.<br/>MATERIALS AND METHODS: C. dactylon extract was subjected to antioxidant (DPPH and H2O2) and<br/>acetylcholinesterase enzyme tests by in vitro methods. Scopolamine (1 mg/kg, i.p) was administered<br/>to rats except for normal control. Donepezil (3 mg/kg, p.o), CDE (100, 200, and 400 mg/kg p.o) were<br/>administered to treatment groups. Behavioral paradigm: Morris water maze (MWM), elevated plus<br/>maze (EPM), and passive avoidance test (PAT) were conducted. Later, rats were sacrificed and<br/>brain homogenate was tested for levels of acetylcholinesterase, glutathione, and lipid peroxidase.<br/>Histopathology examination of cortex and hippocampus of all the groups was done.<br/>STATISTICAL METHOD: The statistical methods used were ANOVA and Tukey’s post hoc test.<br/>RESULTS: CDE antioxidant activity was demonstrated by decreasing DPPH and H 2O2 levels<br/>confirmed through in vitro analysis. Treatment group rats reversed scopolamine induced amnesia<br/>by improvement in spatial memory, decreased transfer latency and increased step through latency<br/>significantly (P<0.001) in behavior models such as morris water maze, elevated plus maze and<br/>passive avoidance task respectively. CDE modulated acetylcholine transmission by decreased<br/>acetylcholinesterase enzyme level (P < 0.001) and scavenging scopolamine‑induced oxidative stress<br/>by increased reduced glutathione levels and decreased lipid peroxidation levels in the rat brain. CDE<br/>and donepezil‑treated rats showed mild neurodegeneration in comparison to scopolamine‑induced<br/>severe neuronal damage on histopathology examination.<br/>CONCLUSION: C. dactylon extract provides evidence of anti‑amnesic activity by the mechanism of<br/>decreased acetylcholinesterase enzyme level and increased antioxidant levels in scopolamine‑induced<br/>amnesia in rats. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16783 |
| Co-Author | Patil, Basanagouda M. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol53150-1838965_050629.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/06/2022 | 2022-0859 | 24/06/2022 | 24/06/2022 | Articles Abstract Database |