Bioavailability enhancement of artemether and lumefantrine by improving solubility and dissolution rate using solid dispersion technique (Record no. 16941)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220628120641.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220628b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16877 |
| Author | Charde, Yogita |
| 245 ## - TITLE STATEMENT | |
| Title | Bioavailability enhancement of artemether and lumefantrine by improving solubility and dissolution rate using solid dispersion technique |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(4), July-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 808-822p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Artemether-lumefantrine is World Health Organization approved fixed dose combination for malaria<br/>treatment. These drugs have poor bioavailability due to low solubility and dissolution. The objective of this<br/>work was to improve bioavailability by increasing solubility and dissolution of both drugs. In this work solid<br/>dispersion using hydrophilic carriers like polyvinylpyrrolidone K-30, Soluplus and Lutrol F68 by solvent<br/>evaporation technique was prepared and evaluated for solubility, flow property, differential scanning<br/>calorimetry, x-ray diffraction analysis, scanning electron microscopy, disintegration and dissolution<br/>study. The drugs were determined simultaneously by high performance liquid chromatography method<br/>using various surfactants in different dissolution media. Solubility of the drugs was increased in all solid<br/>dispersions compared to pure drugs. Flow properties of solid dispersions containing polyvinylpyrrolidone<br/>K-30 were better than other carriers and the disintegration time of immediate release tablet containing<br/>drug and polyvinylpyrrolidone K-30 (1:0.2) was less than other solid dispersions. X-ray diffraction analysis,<br/>differential scanning calorimetry and scanning electron microscopy results indicated decrease in crystalline<br/>nature of drugs and their dissolution rate was enhanced than plain drugs and marketed formulations<br/>in acidic buffer containing myrj 52 (1 %) as dissolution medium. The pharmacokinetic studies in mice<br/>revealed that artemether-lumefantrine solid dispersion immediate release tablet had higher area under<br/>the curve, maximum plasma concentration for artemether and lumefantrine than plain and marketed<br/>tablet. Thus this technique successfully improved solubility, dissolution rate and hence the bioavailability<br/>of artemether and lumefantrine which was determined by single dissolution method. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16878 |
| Co-Author | Avari, Jasmine |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/bioavailability-enhancement-of-artemether-and-lumefantrine-by-improving-solubility-and-dissolution-rate-using-solid-disp.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 28/06/2022 | 2022-0934 | 28/06/2022 | 28/06/2022 | Articles Abstract Database |