Development of ph sensitive polymeric nanoparticle of erythromycin (Record no. 16973)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220629160213.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220629b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16913 |
| Author | Thaarani, B. |
| 245 ## - TITLE STATEMENT | |
| Title | Development of ph sensitive polymeric nanoparticle of erythromycin |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | BRNSS Publication Hub. |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 413-419p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Erythromycin is a macrolide antibiotic used for the treatment of various infections caused by<br/>bacteria. It is also used for Respiratory tract infection, skin infection, syphilis, etc. Erythromycin base was a<br/>poorly water-soluble and acid-labile drug. The bioavailability of Erythromycin was very less about (15–35%). The<br/>absorption site of Erythromycin is the small intestine. pH-responsive polymeric drug delivery system is efficient<br/>delivering the acid instable drugs. Aim: The main objective of the study is to formulate Erythromycin loaded<br/>pH-responsive polymeric nanoparticles was prepared using pHresponsive polymer to prevent the degradation<br/>of acid-labile drug and to evaluate the Polymeric nanoparticle. Materials and Methods: The Erythromycin<br/>Polymeric nanoparticles were prepared by Nano precipitation method using Eudragit L100 as a Polymer and<br/>polyvinyl alcohol (PVA) as stabilizer. The particle size, polydispersity index (PDI), zeta potential, entrapment<br/>efficiency and In-vitro drug release studies were performed for nanoparticle. The compatibility between drug and<br/>polymer was studied by Fourier transform infrared. The nanoparticle was lyophilized and surface morphology<br/>was determined by scanning electron microscope. Excipients were added and formulated into tablet. The<br/>Precompression evaluation of lyophilized powder was carried out. The post-compression evaluation for tablets<br/>and In-vitro release study was performed and compared with marketed tablet. Results: Erythromycin nanoparticle<br/>was formulated and evaluated. It showed the particle size of 270.2 nm with PDI of 0.166 and the zeta potential was<br/>found to be −32.5. The Entrapment efficiency of the ENP 9 Nanoparticle was 96%. Erythromycin loaded tablet<br/>was formulated and evaluated for hardness, weight variation, disintegration, friability, thickness, and diameter. It<br/>was present within the limit. In vitro drug release of the formulated tablet showed 91% drug release in phosphate<br/>buffer pH6.8 at the end of 60 min. Conclusion: Erythromycin nanoparticles were in the nanometer range and it<br/>was stable. Polymeric nanoparticle tablet had the ability to protect the acid-labile drug and it gets dissolved in<br/>the intestine pH 6.8. The nano particulate tablet showed the better release when compared with marketed tablet. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16904 |
| Co-Author | Subramanian, S. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of green pharmacy |
| Place, publisher, and date of publication | Mandsaur B.R. Nahata Smriti Sansthan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.greenpharmacy.info/index.php/ijgp/article/view/3193 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/06/2022 | 2022-0970 | 29/06/2022 | 29/06/2022 | Articles Abstract Database |