Effect of fucoidan on the regulation of antioxidant enzymes in hepatorenal tissues of streptozotocin-induced diabetic rats (Record no. 17227)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730094627.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17396 |
| Author | Somanath, Deepa |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of fucoidan on the regulation of antioxidant enzymes in hepatorenal tissues of streptozotocin-induced diabetic rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1164-1173p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Accumulation of reactive oxygen species resulting from hyperglycemia and inadequate endogenous<br/>antioxidants are responsible for the complications of diabetes. Accumulation of reactive oxygen species in<br/>the cells stimulates apoptosis, which hampers the cell architecture and functions of vital organs. This study<br/>investigates the effect of fucoidan from Sargassum wightii, a potent antioxidant with a regulatory effect<br/>on blood glucose homeostasis, in the liver and kidney of diabetic rats. Diabetes was induced in rats by<br/>administrating streptozotocin 50 mg/kg for 3 consecutive days through intraperitoneal injection. 30 male<br/>Wistar rats were divided into five groups consisting of six animals in each group and they were Group A:<br/>Control group, Group B: Diabetic group, Group C: Diabetic rats treated with metformin hydrochloride<br/>250 mg/kg, Group D: Diabetic rats treated with fucoidan 50 mg/kg, and Group E: Diabetic rats treated<br/>with fucoidan 100 mg/kg. Fucoidan was administrated orally for 4 w after the induction of diabetes.<br/>Superoxide dismutase activity was low in the liver of the diabetic group and it showed 58.5 % activity,<br/>compared with the control group. Fucoidan administration elevated superoxide dismutase and it was<br/>66.5 % and 80.6 % respectively in fucoidan 50 mg/kg and fucoidan 100 mg/kg groups, compared with<br/>the control group while in the metformin group 93.4 % activity was seen. A similar variation in the<br/>superoxide dismutase was observed in the kidney; wherein, administration of fucoidan restored the<br/>superoxide dismutase activity and it was 62.9 % in the fucoidan 50 mg/kg group and 79.5 % in the fucoidan<br/>100 mg/kg group, compared with the control group while in diabetic group 49.4 % and metformin<br/>group 94.2 % activity were observed. The other tested antioxidant enzymes such as catalase, glutathione<br/>peroxidase and glutathione S transferase also showed marked regain in a dose-dependent manner upon<br/>administration of fucoidan. This study inferred that the administration of fucoidan in streptozotocin-<br/>induced diabetic rats improved the antioxidant enzyme activity by moderating the accumulation of<br/>reactive oxygen species and reduced the pathophysiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15872 |
| Co-Author | Vijayakumar. J. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/effect-of-fucoidan-on-the-regulation-of-antioxidant-enzymes-in-hepatorenal-tissues-of-streptozotocininduced-diabetic-rat.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/07/2022 | 2022-1229 | 30/07/2022 | 30/07/2022 | Articles Abstract Database |