Development of sustained release eudragit based matrix tablet of fluvastatin sodium microspheres (Record no. 17243)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220730150851.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220730b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17433 |
| Author | Kanojia, Neha |
| 245 ## - TITLE STATEMENT | |
| Title | Development of sustained release eudragit based matrix tablet of fluvastatin sodium microspheres |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1229-1242p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and<br/>sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried<br/>microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin sodium microspheres<br/>were prepared using polyvinyl pyrollidone K-30 and Poloxamer 407 through solvent evaporation via<br/>freeze drying. We adopted a central composite design to examine the influence of independent variables<br/>viz. drug:polymer (X1) and surfactant (X2) on the t 50 % (Y1), Q90 (Y2) and percentage drug content (Y3)<br/>along with determination of an optimized composition for production of an optimal Fluvastatin sodium<br/>microspheres. Design expert software illustrated that an optimized Fluvastatin sodium microspherescould<br/>be achieved using 1:3.496 drug:polymer and 3.102 % poloxamer 407 which would illustrates t50 %<br/>(36.33 min), Q90 (79.99 %) and percentage drug content (81.589 %). The mean diameter and polydispersity<br/>index of Fluvastatin sodium microspheres using dynamic light scattering was found 0.78 μm and 0.287,<br/>respectively. Sustained release tablet of optimized Fluvastatin sodium microspheres (Fluvastatin sodium<br/>microspheres-sustained release tablet) was manufactured using Eudragit RS 100 and Eudragit RL 100<br/>based granules by wet granulation technique. In vitro drug release kinetics studies were executed to assess<br/>the drug release mechanism from optimized Fluvastatin sodium microspheres and Fluvastatin sodium<br/>microspheres-sustained release tablet. The dissolution level of Fluvastatin sodium was 3.58-fold improved<br/>wthin 2 h through the freeze dried microspheres. Fluvastatin sodium microspheres-sustained release<br/>tablet showed sustained drug release over 24 h and was matched properly to Korsmeyer-Peppas model<br/>with release exponent of 0.5318, which indicated drug release through diffusion and erosion mechanism.<br/>Conclusively, it has been demonstrated that novel combination of freeze dried microspheres and their<br/>Eudragit polymers-based matrix tablet techniques could find great potential for improving drug dissolution<br/>and sustained release of water insoluble drugs along with reduced dosage frequency. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17436 |
| Co-Author | Singh, S. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/development-of-sustained-release-eudragit-based-matrix-tablet-of-fluvastatin-sodium-microspheres.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/07/2022 | 2022-1244 | 30/07/2022 | 30/07/2022 | Articles Abstract Database |