Floating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades (Record no. 17323)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825133841.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 11968 |
| Author | Sunil Kumar |
| 245 ## - TITLE STATEMENT | |
| Title | Floating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 681-688p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim/Background: The objective behind this study was to develop a Microspheres of<br/>Lafuditine using central composite design for gastroretentive drug delivery. Materials and<br/>Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation<br/>method. The present investigation will study the effect of formulation variables (polymer<br/>concentration etc) on the floating behaviour and drug release characteristics for developing<br/>mathematical relationship between them and optimize the formulation with an aim to<br/>minimize onset of floatation, maximize the duration of floatation in stomach in order to<br/>achieve maximum bioavailability and therapeutic efficacy of selected drug. Microspheres<br/>were evaluated for shape, size, melting point, buoyancy time, floating capacity, % yield,<br/>swelling index, and<br/>in-vitro drug release and in-vivo kinetic studies. Results: Results<br/>showed that selected independent variables significantly affect the yield (66-85%),<br/>particle size (3.78-10.62 μm), buoyancy (42.68-95.75%), encapsulation efficiency<br/>(69.32–94.05%), and cumulative drug release from the microspheres (79.02-96.92%).<br/>The interface and quadratic terms were also affect the process variables, it can be said<br/>that to develop and optimize gastroretentive system of Lafuditine with central composite<br/>design (CCD) is a valuable second-degree design which is effective treatment of<br/>H. pylori<br/>mediated infection and also provides a base to localize the drug release in the gastric<br/>region. Conclusion: The gastroretentive floating Microparticulate system of Lafutidine will<br/>enhance the patient compliance and play a vital role in improving patient’s quality of life.<br/>Keywords: Lafutidine, Eudragit, Central composite design,<br/>In-vitro drug release,<br/>Microparticulate system, Sodium bicarbonate. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4645 |
| Co-Author | Tiwari, Abhishek |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-681.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 25/08/2022 | 2022-1373 | 25/08/2022 | 25/08/2022 | Articles Abstract Database |