Utility of different lipids and effect of soya lecithin on sustained delivery of zidovudine via biodegradable solid lipid microparticles: formulation and in-vitro characterization (Record no. 17324)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825142217.0 |
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| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17591 |
| Author | Sathyamoorthy, Nandhakumar |
| 245 ## - TITLE STATEMENT | |
| Title | Utility of different lipids and effect of soya lecithin on sustained delivery of zidovudine via biodegradable solid lipid microparticles: formulation and in-vitro characterization |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 689-696p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Zidovudine (Azidothymidine, AZT) is widely used in the treatment of<br/>Acquired Immuno Deficiency Syndrome (AIDS) and related conditions, either alone or<br/>in combination with other antiviral agents to combat HIV. AZT is a Biopharmaceutical<br/>Classification System (BCS) class III drug and has various disadvantages. Thus, AZT<br/>is a potential candidate for delivery<br/>via lipid-based drug delivery system. Materials<br/>and Methods: In the present work, solid lipid microparticles (SLMs) of Zidovudine<br/>were developed for sustaining the drug release, to overcome or to reduce the hepatic<br/>metabolism and to ensure optimal bioavailability. A total of sixteen formulations of<br/>Zidovudine loaded solid lipid microparticles in two groups viz., one with tripalmitin<br/>and another with trimyristin were prepared by emulsion-solvent evaporation method.<br/>Results: The average particle size and entrapment efficiency of the prepared SLM varied<br/>between 5.48 μm-10.64 μm and 46.92 % and 58.39% respectively. The release of<br/>zidovudine from the SLM varied between 70.47% and 100% at the end of 24 hrs. 80%<br/>of the drug release which is required for obtaining the optimal therapeutic concentration<br/>was achieved by SLM 8. Conclusion: Formulation SLM 8 was considered best with<br/>maximum sustainability in the drug release along with maintaining therapeutic optimum.<br/>The formulation was found stable under stressed conditions. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17592 |
| Co-Author | Vankayala, Devendiran Sundar |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-689.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 25/08/2022 | 2022-1374 | 25/08/2022 | 25/08/2022 | Articles Abstract Database |