Novel glibenclamide–phospholipid complex for diabetic treatment: formulation, physicochemical characterization, and in-vivo evaluation (Record no. 17325)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825143306.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220825b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17593 |
| Author | Rathor, Sandeep |
| 245 ## - TITLE STATEMENT | |
| Title | Novel glibenclamide–phospholipid complex for diabetic treatment: formulation, physicochemical characterization, and in-vivo evaluation |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 697-705p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Formulation of phospholipid complex is an ideal approach to improve the<br/>solubility of poorly soluble drugs. Objectives: This study has been aimed to prepare a novel<br/>glibenclamide-phospholipid complex by using the solvent evaporation technique. Materials<br/>and Methods: Because glibenclamide is a weakly soluble medication, complexing it with<br/>phospholipids is an excellent way to enhance its solubility. The phospholipid complex<br/>of Glibenclamide was produced using the solvent-evaporation technique to enhance its<br/>oral efficacy. The formulation was characterized and evaluated by various parameters<br/>including FTIR, DSC, PXRD, SEM, TEM,<br/>in vitro drug release, and<br/>in vivo pharmacokinetic<br/>studies in Wistar rats plasma. According to studies, the Glibenclamide phosphates<br/>combination is significantly more water-soluble than the physical combination and pure<br/>Glibenclamide. The oral bioavailability of the glibenclamide-phospholipids complex was<br/>measured by using HPLC in Wistar rats’ plasma. Results: There was no substantial<br/>interaction between the medication and the phospholipid in the formulation, according<br/>to the FTIR and PXRD findings. The morphology of the formulation was verified by<br/>SEM and TEM investigations, indicating that the crystalline form had been converted<br/>to an amorphous form. The glibenclamide-phospholipids complex had a greater peak<br/>plasma concentration (5.1 vs. 3.8 g/mL), its AUC was higher (14.65 vs. 11.81 μgh/L),<br/>and its T1/2 was longer (2.4 vs. 3.1 hr), showing that it enhanced drug dissolution<br/>rate. Conclusion: The findings showed that increasing the oral bioavailability of water-<br/>insoluble medicines by phospholipid-complexation is a potential approach. The results<br/>showed that phospholipid-complexation may be used to enhance the oral bioavailability<br/>of water-insoluble drugs. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17594 |
| Co-Author | Bhatt, D.C. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-697_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 25/08/2022 | 2022-1375 | 25/08/2022 | 25/08/2022 | Articles Abstract Database |