Hydroalcoholic carthamus tinctorius l. Extract attenuates tnbs-induced ulcerative colitis in mice via downregulation of inflammation and oxidative stress (Record no. 17337)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220826111337.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17615 |
| Author | Li, Zhang |
| 245 ## - TITLE STATEMENT | |
| Title | Hydroalcoholic carthamus tinctorius l. Extract attenuates tnbs-induced ulcerative colitis in mice via downregulation of inflammation and oxidative stress |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 780-788p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Ulcerative colitis (UC) is distinct by severe inflammation of intestinal epithelial<br/>tissue and more than 2 million people worldwide are affected with ulcerative colitis.<br/>This disease is primarily driven by oxidative stress and inflammation. Objectives: To<br/>identify a safer remedy with less/no adverse effect, we investigated the beneficial ability<br/>of<br/>Carthamus tinctorius L. extracts to alleviate multi-factorial conditions like oxidative<br/>stress, lipid peroxidation, and inflammation in Trinitro benzenesulfonic acid induced<br/>experimental ulcerative colitis in mice. Materials and Methods: Ulcerative colitis in Balb/c<br/>mice were induced by intrarectal administration of TNBS. Hydroalcoholic<br/>Carthamus<br/>tinctorius L. extracts were supplemented orally and all mice were observed and scored<br/>for clinical manifestations. After sacrificing mice, inflammatory markers, colonic oxidative<br/>stress levels, and antioxidant enzymes were measured. Histological features of the colon<br/>were also analyzed. Results: Supplementing the TNBS-induced group with the plant<br/>extracts suppressed oxidative stress, enhanced cytoprotective antioxidants, and reduced<br/>inflammation. The histological evaluation also showed restoration of damaged tissues.<br/>Conclusion: Our findings indicate the curative ability of the hydroalcoholic<br/>Carthamus<br/>tinctorius L. extracts and can be a good therapeutic candidate to treat Ulcerative colitis.<br/>Keywords: Ulcerative colitis, TNBS,<br/>Carthamus tinctorius L., Oxidative stress,<br/>Inflammation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17616 |
| Co-Author | Niu, Zhongbao |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-780.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 26/08/2022 | 2022-1388 | 26/08/2022 | 26/08/2022 | Articles Abstract Database |