Amino acids from urine as possible biomarkers for early detection of vancomycin nephrotoxicity (Record no. 17339)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220826115329.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17618 |
| Author | Nanaware, Harshal R. |
| 245 ## - TITLE STATEMENT | |
| Title | Amino acids from urine as possible biomarkers for early detection of vancomycin nephrotoxicity |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 795-803p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Drug-induced nephrotoxicity is an important therapeutic concern, as many endogenous<br/>compounds are filtered through the kidneys for excretion into urine. Vancomycin is a<br/>drug of last resort used to treat multiple drug-resistant infections, and is primarily used in<br/>paediatrics to treat infections caused by gram-positive organisms resistant to beta-lactam<br/>antibiotics. Vancomycin is primarily (80–90%) excreted through the kidney. To identify<br/>biochemical markers useful for the early diagnosis of nephrotoxicity, amino acid profiling<br/>was performed in young Wistar rats treated with vancomycin. A liquid chromatography-<br/>mass spectrometry-based method was developed for targeted amino acid analysis from<br/>urine samples collected after dosing with vancomycin (300 mg/kg). Alterations in amino<br/>acids levels were observed in urine immediately after the first dosing, and increased<br/>in prominence during the course of treatment. Nephrotoxicity was confirmed using<br/>established methods such as histopathological evaluation and clinical chemistry analysis.<br/>Of note, a significant change in amino acid levels in urine was observed well before any<br/>noticeable increase in traditional markers. This suggests that quantification of amino<br/>acids from urine could be a good alternative to blood-based analysis in neonates and<br/>children as a strategy for the detection of kidney injury at an earlier stage than any<br/>existing methods. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17619 |
| Co-Author | Moorkoth, Sudheer |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-795.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 26/08/2022 | 2022-1390 | 26/08/2022 | 26/08/2022 | Articles Abstract Database |