Study on the effect of phaseolus vulgaris methanol extract on haloperidol and tacrine induced parkinsonism (Record no. 17340)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220826120737.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220826b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17620 |
| Author | Kaur, Balvinder |
| 245 ## - TITLE STATEMENT | |
| Title | Study on the effect of phaseolus vulgaris methanol extract on haloperidol and tacrine induced parkinsonism |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 804-809p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Parkinson’s disease is neurodegenerative disease with no cure till now, there<br/>are treatments that can be explored to ease the symptoms of this disease, and using plant<br/>extract we explore the possibility of neutralizing the adverse symptoms and providing<br/>better quality of life to patients. Purpose: To demonstrate Anti-parkinson’s activity of<br/>Phaseolus vulgaris methanol pod extract by using behavioural models in<br/>Wister Albino<br/>rats. Materials and Methods: Animals were given<br/>Phaseolus vulgaris methanol extract<br/>(PVME) prior Haloperidol and Tacrine induced Parkinsonism. Results:<br/>Phaseolus vulgaris,<br/>family (Leguminosae) is a plant, well known for its Traditional and Ayurvedic application<br/>for the treatment of various diseases. In the present studies,<br/>Phaseolus vulgaris pods<br/>were used to evaluate its Antiparkinson’s activity in behavioral models in Albino rats.<br/>The models used here were Haloperidol-induced catalepsy and Tacrine-induced vacuous<br/>jaw movement.<br/>Phaseolus vulgaris methanol extract (PVME) of 200 and 400 mg/kg were<br/>given to rats prior to inducing Catalepsy. Haloperidol, an Antipsychotic drug that induces<br/>motor symptoms like Parkinson’s disease, PVME administration for 5 days, and on last<br/>day Haloperidol (1mg/kg i.p) was given and catalepsy was observed, it was seen that<br/>PVME reduces catalepsy score in a dose-dependent manner. Behavioral parameters also<br/>observed using Tacrine, which is an Anticholesterase drug induces chewing movements<br/>and orofacial bursts. The results were noted for a duration of 1 hr and found that PVME<br/>400 mg/kg dose significantly reduces the movements and bursts as compared to<br/>200 mg/kg dose. The given results were found close to the standard group (levodopa +<br/>carbidopa). Conclusion: The study conducted on<br/>Phaseolus vulgaris plant pod extract<br/>demonstrates the Neuroprotective activity of plant and its effectiveness to assess<br/>the symptoms of Parkinson’s disease. Antiparkinson’s effect of PVME shown to treat<br/>symptoms of motor dysfunction attributed to its tendency to reduce oxidative stress and<br/>having phenolic content. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17621 |
| Co-Author | Saxena, Jyoti |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-804.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 26/08/2022 | 2022-1391 | 26/08/2022 | 26/08/2022 | Articles Abstract Database |