Synthesis, characterization and comparison of novel poly (sebacic anhydride) biopolymeric implants and microspheres for the controlled release of an anticancer drug (Record no. 17360)
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| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220829161728.0 |
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| fixed length control field | 220829b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17657 |
| Author | Kala, Shabari Girinath |
| 245 ## - TITLE STATEMENT | |
| Title | Synthesis, characterization and comparison of novel poly (sebacic anhydride) biopolymeric implants and microspheres for the controlled release of an anticancer drug |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 429-437p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The purpose of this study was to investigate the comparative drug release kinetics<br/>of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer.<br/>Methods: Poly (sebacic anhydride) was synthesized using a melt-polycondensation<br/>reaction, and its physicochemical properties were determined using gel permeation<br/>chromatography, nuclear magnetic resonance, differential scanning calorimetry, and<br/>Fourier transform infrared techniques. The polymer was used to encapsulate drugs via<br/>the melt moulding technique for implants and the solvent evaporation technique for<br/>microspheres. Results:<br/>In-vitro degradation of implants showed a 95% degradation rate<br/>in 6 days with the disappearance of the anhydride peak due to polymer hydrolysis.<br/>The microspheres of size 63 ± 3 μm were found to be spherical and porous in optical<br/>microscopy images<br/>. In-vitro drug release from implants (85 ± 3.5%) and microspheres<br/>(88 ± 4.5%) in pH 7.4 revealed similar sustained drug release following Higuchi kinetics.<br/>Conclusion: There was no significant difference observed in drug release patterns from<br/>implants and microspheres with the same quantity of polymer. Therefore, poly (sebacic<br/>anhydride) could become a successful candidate for controlling the release of a drug over<br/>a long period of time. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17658 |
| Co-Author | Chinni, Santhivardhan |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-429.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/08/2022 | 2022-1427 | 29/08/2022 | 29/08/2022 | Articles Abstract Database |