Investigating the role and mechanism of octreotide in long standing diabetes-induced cognitive impairment in rats (Record no. 17362)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220829164559.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220829b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17661 |
| Author | Yuan, Qi |
| 245 ## - TITLE STATEMENT | |
| Title | Investigating the role and mechanism of octreotide in long standing diabetes-induced cognitive impairment in rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 448-454p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Octreotide is a somatostatin analogue and it produces beneficial effects in<br/>diabetic-neuropathy. Studies have also shown its beneficial role in Alzheimer disease.<br/>However, the role of octreotide in diabetes-induced cognitive impairment is not explored<br/>yet. Aim: The present study was designed to explore the role and mechanism of<br/>octreotide in long standing diabetes-induced cognitive impairment in an experimental<br/>model. Materials and Methods: Streptozotocin (60 mg/kg)-injected rats were kept for<br/>10 weeks to induce the development of cognitive impairment, which was assessed using<br/>Morris Water Maze test. The learning was assessed by comparing the escape latency<br/>time (ELT) of day 1 with ELT of day 4. The memory was assessed on the 5th day by<br/>measuring the time spent in target quadrant (TSTQ). Three different doses of octreotide<br/>(10, 20 and 40 μg/kg) were administered for the last two weeks. The levels of Nrf2,<br/>reduced glutathione, TBARS, IL-1 and TNF-α were measured in rat brain homogenates.<br/>Results: Treatment with octreotide for two weeks led to significant increase in day<br/>4 ELT and day 5 TSTQ in streptozotocin-injected rats suggesting the improvement in<br/>learning and memory. Moreover, octreotide attenuated streptozotocin-induced increase<br/>in neuroinflammation and oxidative stress. It also increased the nuclear: cytoplasmic<br/>ratio of Nrf2 suggesting the effect of octreotide in increasing the levels of endogenous<br/>antioxidants. Conclusion: Octreotide has the potential to improve learning and memory<br/>in long standing diabetes-induced cognitive dysfunction and its beneficial effects may be<br/>possibly attributed to decrease in neuroinflammation and oxidative stress. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17662 |
| Co-Author | Feng, Jia |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-448_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/08/2022 | 2022-1429 | 29/08/2022 | 29/08/2022 | Articles Abstract Database |