Antidiabetic potential of ficus glomerata roots with a special emphasis on estimation of bioactive compounds by a novel validated HPTLC technique (Record no. 17365)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830094634.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17666 |
| Author | Upadhye, Mohini |
| 245 ## - TITLE STATEMENT | |
| Title | Antidiabetic potential of ficus glomerata roots with a special emphasis on estimation of bioactive compounds by a novel validated HPTLC technique |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 470-478p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The data presented in this article for<br/>Ficus glomerata Linn. belonging to<br/>family Moraceace which is commonly found all over India. This study aimed towards<br/>the development and validation of high-performance thin-layer chromatography (HPTLC)<br/>method for simultaneous estimation of lupeol and quercetin from<br/>Ficus glomerata and<br/>correlate with its antidiabetic potential. Methods: The various fractions of ethanolic<br/>extract of<br/>Ficus glomerata root were prepared. The HPTLC analysis of quercetin and<br/>lupeol which are the important phytoconstituents responsible for various pharmacological<br/>actions was carried out at 525 nm. ICH guidelines were followed to validate this method<br/>for accuracy, precision and repeatability. Results: The linearity range of quercetin and<br/>lupeol were obtained as 400-2400 ng/spot and 1000- 5000 ng/spot respectively.<br/>Percent drug content was highest in diethyl ether fraction (quercetin 2531.8 ng and<br/>lupeol 1400 ng). The limit of detection value (LOD) obtained for quercetin and lupeol was<br/>3.0793 and 3.1645 ng and the limit of quantification (LOQ) was 9.3314 and 9.5895 ng<br/>respectively. This method developed was accurate, precise and simple has shown higher<br/>resolution from other phytoconstituents present in the fractions. The method can be very<br/>effectively applied for analyzing the quality of herbal material and formulations containing<br/>Ficus glomerata. Antidiabetic activity of various fractions of ethanolic extract of<br/>Ficus<br/>glomerata roots was studied on alloxan-induced diabetic rats. Treatment with fractions<br/>was continued for 11 days. The effect of the fractions on glucose was analyzed. Diabetic<br/>rats treated with diethyl ether fraction exhibited a significant (<br/>p<0.05) decrease in glucose<br/>levels, indicating the potential use of<br/>Ficus glomerata in diabetes mellitus. Conclusion:<br/>As per the ICH guidelines, the HPTLC method used for simultaneous estimation of lupeol<br/>and quercetin was accurate, precise and specific. The method used for phytochemical<br/>standardization of various fractions of ethanolic extract of the roots of<br/>Ficus glomerata<br/>and correlated with its antidiabetic activity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17667 |
| Co-Author | Deokate, Uday |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-470.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1432 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |