Evaluation of anticancer potential of mimosa diplotricha ethanolic leaf extract on N-methyl-N- nitroso urea induced colorectal carcinogenesis in wistar albino rats (Record no. 17366)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830095408.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17668 |
| Author | Madathil, Sri Rashmy |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of anticancer potential of mimosa diplotricha ethanolic leaf extract on N-methyl-N- nitroso urea induced colorectal carcinogenesis in wistar albino rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 479-488p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Colorectal Cancer, (CRC) ranks third among global cancer incidence statistics<br/>and occupies fourth position as far as cancer related death is concerned and the aim of<br/>the study is to evaluate the therapeutic potential of<br/>Mimosa diplotricha ethanolic leaf<br/>extract in chemically induced colorectal carcinogenesis in Wistar albino rats. Materials<br/>and Methods: CRC was induced by intrarectal instillation of N-Methyl-N-Nitrosourea<br/>(MNU), 2mg per rat in 0.5ml of distilled water three times a week for five weeks. Rats<br/>were grouped as control, induced, induced and standard drug treated (15mg/kg.bw),<br/>induced and plant extract treated (in two doses 200mg/kg.bw and 400mg/kg.bw) and<br/>normal rats with respective plant extract treatment (200mg/kg.bw and 400mg/kg.bw).<br/>Treatment were carried out for 60 days followed which animals were euthanized and serum<br/>markers, oxidative stress, microbial enzymatic, histological and immunohistochemical<br/>parameters were analysed. Results:<br/>M. diplotricha was found to be effective in the down<br/>regulation of serum inflammatory and tumour markers like tumour necrosis factor alpha,<br/>transforming growth factor beta, carcinoembryogenic antigen and colon cancer specific<br/>antigen-4 levels. Oxidative stress parameters and histological data also supported the<br/>therapeutic efficacy of<br/>M. diplotricha. Expression of anti-apoptotic protein Bcl-2 was also<br/>found be downregulated in induced animals treated with<br/>M. diplotricha as evident from<br/>immunohistochemical data. Conclusion: The results of present research suggest that<br/>M. diplotricha ethanolic leaf extract showed a significant therapeutic potential against<br/>chemically induced colorectal carcinogenesis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17669 |
| Co-Author | Kannappan, Poornima |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-479.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1433 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |