Antioxidant and cytotoxic activity of steroidal alkaloids isolated from sarcococca saligna against DPPH and hela cell lines (Record no. 17367)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830100719.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17670 |
| Author | Jan, Naeem Ullah |
| 245 ## - TITLE STATEMENT | |
| Title | Antioxidant and cytotoxic activity of steroidal alkaloids isolated from sarcococca saligna against DPPH and hela cell lines |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 489-496p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and Objectives: Cancer is believed to be one of the main challenges to<br/>health care profession and compounds isolated from natural products play significant<br/>role in treatment of cancer.<br/>Sarcococca saligna (Buxaceae) contains variety of steroidal<br/>alkaloids having numerous pharmacological and biological potentials. Hence, current<br/>research work was designed to isolate steroidal alkaloids from<br/>Sarcococca saligna and<br/>to evaluate it for antioxidant and cytotoxic activity. Materials and Methods: Compounds<br/>Alkaloid-C, Dictyophlebine, Sarcovagine-D and Holaphylline were purified by column<br/>chromatography followed by spectroscopic techniques for their structure confirmation.<br/>Antioxidant and cytotoxic activities were investigated against DPPH and HeLa cell lines<br/>using ascorbic acid and doxorubicin as standard. Results: The radical scavenging effect<br/>produced by Holaphylline and Sarcovagine-D was 80.0±3.20 and 78.0±3.20 % at<br/>400 μg/ml concentration which was statistically similar to that of standard, while on the<br/>same concentration inhibition for Dictyophlebine and Alkaloid-C was 10.0±0.00% and<br/>20±1.01 %. In addition, Holaphylline showed less anticancer activity (23.88±0.243)<br/>in cell growth of HeLa cell followed by Alkaloid-C (12.9±0.235), Dictyophlebine<br/>(6.1±0.345), while S cytotoxic effect for Sarcovagine-D was high (5.1±0.14) in (IC 50<br/>),<br/>which exhibiting statistical variation from Doxorubicin (2.1±0.14%). Conclusion: This<br/>study provided scientific report and importance of the use of steroidal alkaloids from<br/>Sarcococca saligna as an antioxidant and cytotoxic against agents’ HeLa cell lines that<br/>may provide a new scope toward the development of novel drugs for cancer remedy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17671 |
| Co-Author | Kifayatullah, Muhammad |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-489.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1434 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |