Bioguided Isolation of Alternariol Derivatives fromFicus-derived Endophyte Alternaria alternata (Record no. 17368)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830104122.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15193 |
| Author | Abdou, Randa |
| 245 ## - TITLE STATEMENT | |
| Title | Bioguided Isolation of Alternariol Derivatives fromFicus-derived Endophyte Alternaria alternata |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 497-502p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Endophytes are a rich source of bioactive natural products and suggested<br/>to contribute to the biological or defense activities of their host plants. Following our<br/>research on the discovery of bioactive metabolites from endophytes,<br/>Alternaria alternata<br/>was isolated from the leaves of<br/>Ficus carica L. fam<br/>Moraceae. Materials and Methods:<br/>Large scale cultivation of the endophytic strain was carried out and the obtained extract<br/>was subjected to preliminary screening of antifungal and cytotoxic activities. Results:<br/>Promising antifungal and cytotoxic activities were obtained for the extract. Bio-guided<br/>fractionation resulted in the isolation and identification of four alternariol derivatives<br/>(alternariol, alternariol-5-O-sulphate, alternariol-5-O-methyl ether, alternariol-5-O-methyl<br/>ether-4`-O-sulphate). The isolated compounds were tested for antifungal and cytotoxic<br/>effects. Results revealed highest antifungal activity for alternariol against<br/>A. terreus<br/>(MIC= 2.64 μg mL -1<br/>) and<br/>F. oxysporum (MIC= 36 μg mL -1<br/>) while alternariol-5-O-methyl<br/>ether exhibited the highest cytotoxicity against K-562 (CC50<br/>= 3.72 μg mL-1<br/>) and HUVEC<br/>(CC50<br/>= 2.06 μg mL-1<br/>) cell lines. Conclusion: All alternariol derivatives showed potent<br/>cytotoxic and antifungal activities against<br/>A. terreus suggesting the contribution of this<br/>endophyte in the known antimicrobial and anticancer activities of the host plant. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17672 |
| Co-Author | Attia, Gouda H. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-497.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1441 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |